Frontiers of Model Animals for Neuroscience : Animal Models of Autism Spectrum Disorder (ASD) : A Synaptic-Level Approach to Autistic-Like Behavior in Mice

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  • SHINODA Yo
    Department of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan CREST/JST, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan
  • SADAKATA Tetsushi
    CREST/JST, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan Advanced Scientific Research Leaders Development Unit, Gunma University, 3-39-22 Showamachi, Maebashi, Gunma 371-8511, Japan
  • FURUICHI Teiichi
    Department of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan CREST/JST, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan RIKEN BSI, 2-1 Wako, Saitama 351-0198, Japan

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タイトル別名
  • Animal Models of Autism Spectrum Disorder (ASD): A Synaptic-Level Approach to Autistic-Like Behavior in Mice

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Autism spectrum disorder (ASD) is one of the most common neurodevelopmental disorders and is thought to be closely associated with genetic factors. It is noteworthy that many ASD-associated genes reported by genome-wide association studies encode proteins related to synaptic formation, transmission, and plasticity. Therefore, it is essential to elucidate the relationship between deficiencies in these genes and the relevant ASD-related phenotypes using synaptic and behavioral phenotypic analysis of mice that are genetically modified for genes related to ASD (e.g., knockout or mutant mice). In this review, we focus on the behavioral-, cellular-, and circuit-level phenotypes, including synaptic formation and function, of several knockout mouse models with genetic mutations related to ASD. Moreover, we introduce our recent findings on the possible association of the dense-core vesicle secretion-related gene CAPS2/CADPS2 with ASD by using knockout mice. Finally, we discuss the usefulness and limitations of various mouse models with single gene mutations for understanding ASD.

収録刊行物

  • Experimental Animals

    Experimental Animals 62 (2), 71-78, 2013

    公益社団法人 日本実験動物学会

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