Assessment of liver fibrosis by ultrasound elastography and contrast-enhanced ultrasound: a randomized prospective animal study

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  • Qiu Tingting
    Department of Ultrasound, West China Hospital Sichuan University, No.37 Guo Xue Xiang, Wu Hou District, Chengdu 610041, P.R. China
  • Wang Hong
    Department of Ultrasound, West China Hospital Sichuan University, No.37 Guo Xue Xiang, Wu Hou District, Chengdu 610041, P.R. China
  • Song Jinzhen
    Department of Ultrasound, West China Hospital Sichuan University, No.37 Guo Xue Xiang, Wu Hou District, Chengdu 610041, P.R. China
  • Ling Wenwu
    Department of Ultrasound, West China Hospital Sichuan University, No.37 Guo Xue Xiang, Wu Hou District, Chengdu 610041, P.R. China
  • Shi Yujun
    Research Institute of Pathology, West China Hospital Sichuan University, No.88 Ke Yuan South Road, Wu Hou District, Chengdu 610041, P.R. China
  • Guo Gang
    Research Institute of Pathology, West China Hospital Sichuan University, No.88 Ke Yuan South Road, Wu Hou District, Chengdu 610041, P.R. China
  • Luo Yan
    Department of Ultrasound, West China Hospital Sichuan University, No.37 Guo Xue Xiang, Wu Hou District, Chengdu 610041, P.R. China

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Abstract

<p>This study aimed to assess liver fibrosis by contrast-enhanced ultrasound (CEUS) and point shear-wave elastography (pSWE) in rabbits and compare the performance of the two techniques. Eighty rabbits were divided into experimental (n=60) and control group (n=20). In the experimental group, liver fibrosis (F1–F4) was induced by subcutaneous injection of carbon tetrachloride. CEUS and pSWE of the liver was performed for the two groups at a 4-week interval for 40 weeks. The portal vein rise time (PV-RT), time to peak (PV-TTP), mean transit time (PV-MTT) and the maximum signal intensity (PV-Imax) were analyzed with time-intensity curves (TICs). Liver stiffness value (LSV) was obtained through pSWE. Histologic examination of liver specimens of the rabbits was performed to evaluate the fibrosis stage. PV-RT, PV-TTP, PV-Imax and LSV were significantly different among five liver fibrosis stages (F0–F4) (P<0.01). PV-Imax and LSV displayed better diagnostic performance than PV-RT, PV-TTP, PV-MTT. For diagnosing≥F1 stage fibrosis, the area under the receiver operating characteristic curve (AUROC) of PV-Imax was 0.870, which was similar to that of LSV 0.874 (P=0.94). For diagnosing ≥F2, ≥F3 and ≥F4 stage fibrosis, the AUROC of PV-Imax and LSV was 0.845 vs. 0.956 (P=0.04), 0.789 vs. 0.954 (P=0.01) and 0.707 vs. 0.933 (P=0.03). Both CEUS and pSWE had the potential to be complementary imaging tools in the evaluation of liver fibrosis. The performance of pSWE may be better than CEUS.</p>

Journal

  • Experimental Animals

    Experimental Animals 67 (2), 117-126, 2018

    Japanese Association for Laboratory Animal Science

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