Sequence Determination of the Heavy-Chain Constant Region in Four Immunoglobulin Classes of Mongolian Gerbils (Meriones unguiculatus)

DOI Web Site Web Site PubMed 被引用文献1件 参考文献32件
  • Ukaji Takao
    Department of Animal Science and Resources, College of Bioresource Sciences, Nihon University
  • Sumiyama Daisuke
    Department of Animal Science and Resources, College of Bioresource Sciences, Nihon University
  • Kai Osamu
    Department of Animal Science and Resources, College of Bioresource Sciences, Nihon University

書誌事項

タイトル別名
  • Sequence Determination of the Heavy-Chain Constant Region in Four Immunoglobulin Classes of Mongolian Gerbils (<i>Meriones unguiculatus</i>)

この論文をさがす

抄録

We determined partial cDNA sequences of four immunoglobulin (Ig) classes—IgM, IgG1, IgE, and IgA—of Mongolian gerbil (Meriones unguiculatus). Each deduced Ig heavy-chain constant (IGHC) region—Cμ, Cγ1, Cε, and Cα—is structurally similar to its counterparts in the mouse and rat, and phylogenetic analysis suggests that the gerbil Igs are evolutionarily close to their counterparts. In spite of the high sequence homology to the other rodent Cγ sequences, the gerbil Cγ1 sequence differs from our previously reported Cγ2. This result indicates that the gerbil has at least two IgG subclasses. These four gerbil IGHC cDNA sequences will be useful for determining gerbil Ig isotypes and examining the expression of gerbil Ig mRNAs in response to parasitic and bacterial infections.<br>

収録刊行物

  • Experimental Animals

    Experimental Animals 61 (2), 99-107, 2012

    公益社団法人 日本実験動物学会

被引用文献 (1)*注記

もっと見る

参考文献 (32)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ