5-HT1A and 5-HT1B receptors in the ventrolateral striatum differentially modulate apomorphine-induced jaw movements in rats
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- Fujita Satoshi
- Department of Pharmacology, Nihon University School of Dentistry
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- Kiguchi Motori
- Department of Orthodontics, Nihon University School of Dentistry
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- Lee Jun
- Department of Complete Denture Prosthodontics, Nihon University School of Dentistry
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- Terakado Masanori
- Department of Pharmacology, Nihon University School of Dentistry
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- Suga Kurando
- Department of Pharmacology, Nihon University School of Dentistry
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- Hatanaka Hiroshige
- Department of Pharmacology, Nihon University School of Dentistry
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- Koshikawa Noriaki
- Department of Pharmacology, Nihon University School of Dentistry Division of Oral and Craniomaxillofacial Research, Dental Research Center, Nihon University School of Dentistry
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説明
The ability of serotonin 5-HT1A and 5-HT1B receptors in the ventrolateral striatum to modulate dopamine receptor-mediated jaw movements was investigated in freely moving rats, using a magnet-sensing system combined with an intracerebral drug microinjection technique. Apomorphine (1 mg/kg i.v.) has been found to elicit repetitive jaw movements. Bilateral injections of the 5-HT1A receptor agonist 8-OH-DPAT (1 and 4 μg/0.2 μl in each side) into the ventrolateral striatum partially but significantly reduced apomorphine-induced repetitive jaw movements. The 5-HT1A receptor antagonist WAY-100635 (1 μg), which alone did not affect the effects of apomorphine, antagonized the inhibitory effects of 8-OH-DPAT (4 μg). Bilateral injections of the 5-HT1B receptor agonist CP93129 (1 and 10 μg) also reduced apomorphine-induced repetitive jaw movements in a dose-dependent manner. However, the 5-HT1B receptor antagonist GR55562 (1 and 10 μg) did not antagonize the inhibitory effects of CP93129 (10 μg). These results suggest that 5-HT1A, but not 5-HT1B, receptors in the ventrolateral striatum play a modulatory role in the production of dopamine receptor-mediated jaw movements. (J. Oral Sci. 50, 387-395, 2008)
収録刊行物
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- Ｊｏｕｒｎａｌ ｏｆ Ｏｒａｌ Ｓｃｉｅｎｃｅ
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Ｊｏｕｒｎａｌ ｏｆ Ｏｒａｌ Ｓｃｉｅｎｃｅ 50 (4), 387-395, 2008
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