Introduction to the Japan Mouse Clinic at the RIKEN BioResource Center

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  • WAKANA Shigeharu
    Technology and Development Team for Mouse Phenotype Analysis, RIKEN BioResource Center
  • SUZUKI Tomohiro
    Technology and Development Team for Mouse Phenotype Analysis, RIKEN BioResource Center
  • FURUSE Tamio
    Technology and Development Team for Mouse Phenotype Analysis, RIKEN BioResource Center
  • KOBAYASHI Kimio
    Technology and Development Team for Mouse Phenotype Analysis, RIKEN BioResource Center
  • MIURA Ikuo
    Technology and Development Team for Mouse Phenotype Analysis, RIKEN BioResource Center
  • KANEDA Hideki
    Technology and Development Team for Mouse Phenotype Analysis, RIKEN BioResource Center
  • YAMADA Ikuko
    Technology and Development Team for Mouse Phenotype Analysis, RIKEN BioResource Center
  • MOTEGI Hiromi
    Team for Advanced Development and Evaluation of Human Disease Models, RIKEN BioResource Center
  • TOKI Hideaki
    Team for Advanced Development and Evaluation of Human Disease Models, RIKEN BioResource Center
  • INOUE Maki
    Team for Advanced Development and Evaluation of Human Disease Models, RIKEN BioResource Center
  • MINOWA Osamu
    Team for Advanced Development and Evaluation of Human Disease Models, RIKEN BioResource Center
  • NODA Tetsuo
    Team for Advanced Development and Evaluation of Human Disease Models, RIKEN BioResource Center
  • WAKI Kazunori
    Technology and Development Unit for Knowledge Base of Mouse Phenotype, RIKEN BioResource Center
  • TANAKA Nobuhiko
    Technology and Development Unit for Knowledge Base of Mouse Phenotype, RIKEN BioResource Center
  • MASUYA Hiroshi
    Technology and Development Unit for Knowledge Base of Mouse Phenotype, RIKEN BioResource Center
  • OBATA Yuichi
    RIKEN BioResource Center

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抄録

A systematic and comprehensive phenotyping platform has been developed by the RIKEN ENU-mutagenesis project between 1999 and 2007. As a result of phenotype screening on this platform, we have discovered about 400 mutants as animal models for human diseases. All information regarding these mouse mutants is now available to the public through our home page (http://www.brc.riken.jp/lab/gsc/mouse/indexJ.html). In 2008, we reconstructed the existing phenotyping platform and built a new platform. The new system has a hierarchical structure, consisting of a fundamental pipeline that utilizes the existing platform and an additional pipeline, which is optimized for more in-depth phenotyping assays. Using this system, we have started to perform more comprehensive phenotyping of mouse mutants. We have opened this system to Japanese scientists as the Japanese Mouse Clinic. It is anticipated that existing mouse mutants will be reevaluated as disease models by identifying novel phenotypes on the new platform. We will share detailed information about the standard operating procedures (SOPs) of our phenotyping analyses with other related large-scale projects, such as the European Mouse Disease Clinic (EUMODIC) and the German Mouse Clinic (GMC). Moreover, we will contribute to international efforts to standardize mouse phenotype data by sharing annotation of mutant phenotypes, which are made by internationally standardized methods, with other related projects.<br>

収録刊行物

  • Experimental Animals

    Experimental Animals 58 (5), 443-450, 2009

    公益社団法人 日本実験動物学会

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