Introduction to the Japan Mouse Clinic at the RIKEN BioResource Center
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- WAKANA Shigeharu
- Technology and Development Team for Mouse Phenotype Analysis, RIKEN BioResource Center
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- SUZUKI Tomohiro
- Technology and Development Team for Mouse Phenotype Analysis, RIKEN BioResource Center
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- FURUSE Tamio
- Technology and Development Team for Mouse Phenotype Analysis, RIKEN BioResource Center
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- KOBAYASHI Kimio
- Technology and Development Team for Mouse Phenotype Analysis, RIKEN BioResource Center
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- MIURA Ikuo
- Technology and Development Team for Mouse Phenotype Analysis, RIKEN BioResource Center
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- KANEDA Hideki
- Technology and Development Team for Mouse Phenotype Analysis, RIKEN BioResource Center
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- YAMADA Ikuko
- Technology and Development Team for Mouse Phenotype Analysis, RIKEN BioResource Center
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- MOTEGI Hiromi
- Team for Advanced Development and Evaluation of Human Disease Models, RIKEN BioResource Center
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- TOKI Hideaki
- Team for Advanced Development and Evaluation of Human Disease Models, RIKEN BioResource Center
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- INOUE Maki
- Team for Advanced Development and Evaluation of Human Disease Models, RIKEN BioResource Center
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- MINOWA Osamu
- Team for Advanced Development and Evaluation of Human Disease Models, RIKEN BioResource Center
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- NODA Tetsuo
- Team for Advanced Development and Evaluation of Human Disease Models, RIKEN BioResource Center
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- WAKI Kazunori
- Technology and Development Unit for Knowledge Base of Mouse Phenotype, RIKEN BioResource Center
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- TANAKA Nobuhiko
- Technology and Development Unit for Knowledge Base of Mouse Phenotype, RIKEN BioResource Center
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- MASUYA Hiroshi
- Technology and Development Unit for Knowledge Base of Mouse Phenotype, RIKEN BioResource Center
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- OBATA Yuichi
- RIKEN BioResource Center
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説明
A systematic and comprehensive phenotyping platform has been developed by the RIKEN ENU-mutagenesis project between 1999 and 2007. As a result of phenotype screening on this platform, we have discovered about 400 mutants as animal models for human diseases. All information regarding these mouse mutants is now available to the public through our home page (http://www.brc.riken.jp/lab/gsc/mouse/indexJ.html). In 2008, we reconstructed the existing phenotyping platform and built a new platform. The new system has a hierarchical structure, consisting of a fundamental pipeline that utilizes the existing platform and an additional pipeline, which is optimized for more in-depth phenotyping assays. Using this system, we have started to perform more comprehensive phenotyping of mouse mutants. We have opened this system to Japanese scientists as the Japanese Mouse Clinic. It is anticipated that existing mouse mutants will be reevaluated as disease models by identifying novel phenotypes on the new platform. We will share detailed information about the standard operating procedures (SOPs) of our phenotyping analyses with other related large-scale projects, such as the European Mouse Disease Clinic (EUMODIC) and the German Mouse Clinic (GMC). Moreover, we will contribute to international efforts to standardize mouse phenotype data by sharing annotation of mutant phenotypes, which are made by internationally standardized methods, with other related projects.<br>
収録刊行物
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- Experimental Animals
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Experimental Animals 58 (5), 443-450, 2009
公益社団法人 日本実験動物学会
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詳細情報 詳細情報について
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- CRID
- 1390001205046258688
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- NII論文ID
- 130000122254
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- NII書誌ID
- AA11032321
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- ISSN
- 18817122
- 00075124
- 13411357
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- NDL書誌ID
- 10810032
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可
