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- TANABE Kiyokatsu
- Department of Medical Zoology, Faculty of Medicine, Kagoshima University
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- GOTO Hajime
- Department of Infectious Diseases, Institute of Medical Science, University of Tokyo
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- SHIMADA Kaoru
- Department of Infectious Diseases, Institute of Medical Science, University of Tokyo
Bibliographic Information
- Other Title
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- ペンタミジン吸入投与によるニューモシスチスカリニ肺炎の治療成績
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Description
Our retrospective study for ultrasonic nebulised pentamidine in 13 patients shows that 7 of 8 patients with Pneumocystis carinii pneumonia (PCP), proven by biopsy examination, were cured (recovery rate, 88%). Two of these 8 patients were mainly treated by nebulised pentamidine and the other 5 patients were administered parenteral pentamidine before the nebulised pentamidine therapy and the final 1 patient died on day 9 without clinical improvement with nebulised pentamidine as well as conventional therapy (trimethoprim-sulphamethoxazole, parenteral pentamidine). No relapse occurred in the 7 cured patients.<BR>The inhalation increased the cough in 4 of 13 cases and caused vomitng in 1 patient. Two patients discontinued the nebulisation because of the side-effect. No extra-pulonary side-effects of nebulise dpentamidine were seen.<BR>These results show that an efficacy of nebulised pentamidine is at least equal to conventionaltherapy with fewer side-effects and that only patients with mild PCP without severe hypoxaemia are eligible for the inhalation therapy.
Journal
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- Kansenshogaku Zasshi
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Kansenshogaku Zasshi 65 (3), 299-303, 1991
The Japanese Association for Infectious Diseases