Basic and Clinical Studies of Pazufloxacin on Infectious Enteritis Research Group of T-3761 on Infectious Enteritis (Manager; Shoichiro IRIMAJIRI)

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  • SAGARA Hiroko
    Department of Infectious Diseases, Yokohama Municipal Citizen's Hospital
  • YOSHIKAWA Kouji
    Department of Infectious Diseases, Yokohama Municipal Citizen's Hospital
  • TOMIZAWA Isao
    Department of Infectious Diseases, Minamigaoka Branch, Sapporo City General Hospital
  • TAKIZAWA Yoshihiko
    Department of Infectious Diseases, Minamigaoka Branch, Sapporo City General Hospital
  • NITTA Yoshiro
    Department of Infectious Diseases, Tokyo Metropolitan Toshima General Hospital
  • TSUNODA Takafumi
    Department of Infectious Diseases, Tokyo Metropolitan Toshima General Hospital
  • FUKUDA Hiroyuki
    Department of Infectious Diseases, Tokyo Metropolitan Toshima General Hospital
  • YAMAGUCHI Tsuyoshi
    Department of Infectious Diseases, Tokyo Metropolitan Komagome General Hospital
  • MASUDA Gohta
    Department of Infectious Diseases, Tokyo Metropolitan Komagome General Hospital
  • NEGISHI Masayoshi
    Department of Infectious Diseases, Tokyo Metropolitan Komagome General Hospital
  • AJISAWA Atsushi
    Department of Infectious Diseases, Tokyo Metropolitan Komagome General Hospital
  • MURATA Misako
    Department of Infectious Diseases, Tokyo Metropolitan Bokutoh General Hospital
  • OHNISHI Kenji
    Department of Infectious Diseases, Tokyo Metropolitan Bokutoh General Hospital
  • IRIMAJIRI Shoichiro
    Department of Internal Medicine, Kawasaki Municipal Hospital
  • OBANA Mitsuo
    Department of Internal Medicine, Kawasaki Municipal Hospital
  • MATSUMOTO Fumio
    Department of Internal Medicine, Kanagawa Prefectural Midwives Nurses Training Hospital
  • IMAI Takero
    Department of Internal Medicine, Kanagawa Prefectural Midwives Nurses Training Hospital
  • SAKURAI Iwao
    Department of Internal Medicine, Kanagawa Prefectural Midwives Nurses Training Hospital
  • TAKAHASHI Takayuki
    Department of Internal Medicine, Kanagawa Prefectural Midwives Nurses Training Hospital
  • MORI Masamiki
    Department of Communicable Diseases, Nagoya City Higashi General Hospital
  • MIZUNO Yoshiki
    Department of Communicable Diseases, Nagoya City Higashi General Hospital
  • KATOH Kohji
    Department of Communicable Diseases, Nagoya City Higashi General Hospital
  • HOSODA Shiro
    Decond Department of Internal Medicine, Shiga Univresity of Medical Science
  • BAMBA Tadao
    Decond Department of Internal Medicine, Shiga Univresity of Medical Science
  • SASAKI Masaya
    Decond Department of Internal Medicine, Shiga Univresity of Medical Science
  • YOSHIKAWA Kunio
    Department of Internal Medicine, Nagahama Red Cross Hospital
  • HIROTANI Shuichi
    Department of Internal Medicine, Nagahama Red Cross Hospital
  • OGASAWARA Takeshi
    Department of Internal Medicine, Otsu Municipal Hospital
  • SAKUMOTO Hitoshi
    Department of Internal Medicine, Otsu Municipal Hospital
  • KOMAI Yasunobu
    Department of Internal Medicine, Otsu Municipal Hospital
  • OOKUBO Hideo
    Department of Communicable Diseases, Kyoto City Hospital
  • KIM Young Ki
    Department of Communicable Diseases, Kyoto City Hospital
  • NAKAJO Shinobu
    大阪府済生会吹田病院内科
  • OBATA Hirozumi
    大阪府済生会吹田病院内科
  • SAKAUE Yoshihiro
    Infectious Disease Center, Osaka City General Hospital
  • YOSHIDA Hideki
    Infectious Disease Center, Osaka City General Hospital
  • GOTO Tetsushi
    Infectious Disease Center, Osaka City General Hospital
  • AISAKA Tadakazu
    Department of Internal Medicine, Hiroshima City Funairi Hospital
  • MIKAMI Motoko
    Department of Internal Medicine, Hiroshima City Funairi Hospital
  • KAGAWA Kazunori
    Department of Internal Medicine, Kure National Hospital
  • IMAGAWA Yatsuka
    College of Enviromental Health, Azabu University
  • FUKUYAMA Masafumi
    College of Enviromental Health, Azabu University
  • MATSUBARA Yoshio
    Department of Internal Medicine, Kiyose Jogu Hospital
  • SAITO Makoto
    Showa University

Bibliographic Information

Other Title
  • Pazufloxacin (PZFX) の感染性腸炎に対する基礎的・臨床的検討
  • Pazufloxacin PZFX ノ カンセンセイ チョウ エン ニ タイス

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Abstract

A clinical study was carried out on pazufloxacin (PZFX) in 137 patients including shigellosis, Salmonella enteritis, enteropathogenic Esherichia coli enteritis and cholera, and carriers of these pathogens. Antibacterial activity of PZFX against clinical isolates, fecal concentration of PZFX and effects of PZFX on fecal microflora were also investigated.<BR>The overall clinical efficacy rate was 97.2%.<BR>The bacteriological efficacy rates were 98.2% against Shigella spp., 81.8% against Salmonella spp., 50% against Vibrio cholerae 01, and 100% against E. coli, V. parahaemolyticus, Aeronomas spp., Plesionomas shigelloides and V. cholerae non-01, respectively.<BR>Side effect (epigastralgia) was observed in 1 of 130 cases (0.8%).The rate of abnormal laboratory findings was 11.2%(11/98). These were mainly elevation of GOT and/or GPT and increased eosinophils.<BR>The clinical usefulness rate was 95.2%.<BR>The MIC90 values of PZFX against Shigella spp., Salmonella spp. and E. coli were 0.025, 0.025 and 0.025, μg/ml, respectively.<BR>The results of fecal drug concentration and the effects on fecal microflora in one patient were compatible with those obtained in healthy volunteers.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 70 (1), 60-72, 1996

    The Japanese Association for Infectious Diseases

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