Mechanism of Fertilization: A Modern View

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  • OKABE Masaru
    Center for Genetic Analysis for Biological Responses, Research Institute for Microbial Diseases, Osaka University, Yamadaoka 3-1, Suita, Osaka 565-0871, Japan

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説明

Despite numerous studies on mammalian fertilization, the mechanisms of fertilization—including the timing of acrosome reaction—remain largely unknown; more accurately described, the classical theory built upon years of layered experimental data is being challenged by recent conflicting evidence provided by gene-manipulated animals. Although in vitro fertilization remains our central research tool, the classical theory’s decline reminds us of the importance of in vivo observations. Here, I describe the essential roles of gene-manipulated animals in elucidating the mechanism of fertilization and the pitfalls of in vitro fertilization studies trapping many researchers.

収録刊行物

  • Experimental Animals

    Experimental Animals 63 (4), 357-365, 2014

    公益社団法人 日本実験動物学会

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