Antibody Response of Inactivated Influenza Vaccine in the Elderly
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- YAMAKOSHI Masahiro
- Nagoyashi-Koseiin Geriatric Hospital
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- SUZUKI Kanzou
- Nagoyashi-Koseiin Geriatric Hospital
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- YAMAMOTO Toshinobu
- Nagoyashi-Koseiin Geriatric Hospital
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- YAMAMOTO Toshiyuki
- Nagoyashi-Koseiin Geriatric Hospital
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- GOTO Noriko
- Nagoya City Public Health Research Institute
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- NAKAKITA Takasi
- Nagoya City Public Health Research Institute
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- YAMADA Yasuo
- First Department of Internal Medicine, Nagoya City University Medical School
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- ITOH Makoto
- First Department of Internal Medicine, Nagoya City University Medical School
Bibliographic Information
- Other Title
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- 高齢者におけるインフルエンザワクチンの抗体産生能の検討
- コウレイシャ ニ オケル インフルエンザ ワクチン ノ コウタイ サンセイノウ
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Abstract
The antibody responses of 31 elderly persons (11 males and 20 females, mean 82.2 years) and 23 adults (mean 40.7 years) to inactivated influenza vaccine were studied. Participants were given twice the influenza vaccine containing A/Yamagata/32/89, A/Kitakyusyu/159/93, and B/ Mie/1/93. Serum specimens were obtained before vaccination, and 2 weeks and 3 months after the second vaccination. Antibody to influenza was determined by hemagglutination inhibition test (HI).<BR>The rates of fourfold or greater increases of HI antibody agaisnt the A/Yamagata, A/ Kitakyusyu, and B/Mie were 96.8%, 100%, and 74.2%, and there was no significant difference of the rates of fourfold or greater increases between elderly persons and adults. The rates of possession of HI antibody more than 128 in titer after vaccination were significantly higher than those of HI antibody before vaccination, and were maintained at high levels up to three months after the second vaccination.<BR>These results suggest that antibody response to the inactivated influenza vaccine is satisfactory in the elderly.
Journal
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- Kansenshogaku Zasshi
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Kansenshogaku Zasshi 72 (4), 358-364, 1998
The Japanese Association for Infectious Diseases
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Keywords
Details 詳細情報について
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- CRID
- 1390001205047233152
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- NII Article ID
- 130004330664
- 10007742756
- 10008717773
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- NII Book ID
- AN00047715
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- ISSN
- 1884569X
- 03875911
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- NDL BIB ID
- 4482706
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- PubMed
- 9621564
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed