Hepatosplenic Candidiasis in Acute Non-Lymphocytic Leukemia

DOI Web Site PubMed 1 Citations
  • MIYAZAKI Sei
    Department of Internal Medicine, Hakodate Municipa Hlospital
  • MIURA Akira
    Third Department of Internal Medicine, Akita University School of Medicine

Bibliographic Information

Other Title
  • 急性非リンパ性白血病に合併した肝脾カンジダ症の臨床的検討
  • キュウセイ ヒ リンパセイ ハッケツビョウ ニ ガッペイシタ カン ヒ カンジ

Search this article

Abstract

Eleven patients with acute non-lymphocytic leukemia developed hepatosplenic candidiasis following the termination of chemotherapy. Five who did not receive amphoteicin B (AMPH) died of liver failure, whereas the other six who received AMPH and/or miconazole or fluconazole were cured.The features of hepatosplenic candidiasis included prolonged high fever not responsive to antibiotics and hepatomegaly with right-sided hypochondrial pain developing after severe neutropenia. Even if the neutropenia recovered, these symptoms did not subside. In addition, elevation of the serum alkaline phosphatase and total bilirubin levels were observed at onset. CT scan revealed multiple low-density areas of varying size that showed no contrast enhancement. Ultrasonography also demonstrated hypoechoic or hyperechoic lesions, and a so-called “target sign appearance” in the liver and spleen. The clinical diagnosis for hepatosplenic candidiasis is not so difficult because of the uniform symptoms, signs and laboratory abnormalities. The importance of the early administration of antifungal agents to obtain a cure is discussed in this article.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 65 (7), 794-798, 1991

    The Japanese Association for Infectious Diseases

Citations (1)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top