Cellular Analysis in Bronchoalveolar Lavage Fluid in Hamsters Infected with <I>Mycoplasma pneumoniae</I>

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  • YANO Takafumi
    The First Department of Internal Medicine, Kurume University School of Medicine

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  • <I>Mycoplasma pneumoniae</I>肺感染実験系における気管支肺胞洗浄液の細胞動態
  • Mycoplasma pneumoniae肺感染実験系における気管支肺胞洗浄液の細胞動態
  • Mycoplasma pneumoniae ハイ カンセン ジッケンケイ ニ
  • Cellular Analysis in Bronchoalveolar Lavage Fluid in Hamsters Infected with Mycoplasma pneumoniae

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Abstract

The pathogenesis of Mycoplasma pneumoniae (M. pn.) induced pneumonia is poorly understood. In the present study, the cellular analysis in BALF and pathologic studies of the lung in both young and adult hamsters infected with M. pn. were performed to investigate the kinetics of inflammatory and immunologic events in M. pn. induced pneumonia. The results are as follows;<BR>1. The titers of mycoplasmacidal antibody in serum of both hamsters were elevated in all cases.<BR>2. Isolation of M. pn. from trachea and BALF of both hamsters reached its highest point of development on 7th day after inoculation, and the number of organisms isolated from trachea and BALF of young hamsters were as much as those of adult hamsters.<BR>3. Transtracheal inoculation of M. pn. into adult hamsters caused bronchitis, perivasculitis and alveolitis characterized the infiltrations with polymorphonuclear leucocytes (PMNs) against a background of mononuclear cells on 7th day after inoculatin. In cellular analysis in BALF, high population of PMNs in BALF on 7th day and high population of lymphocytes in BALF on 21th day were recognized.<BR>4. In case of young hamsters, there were much less severe lung lesions and there were almost no appearances of PMNs in BALF and lung tissues.<BR>These results indicate the importance of cell-mediated reaction in the pathogenesis of M. pn. infection, particularly the infiltration of PMNs appear to play an important role in the early stage of M. pn. induced pneumonia.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 61 (1), 87-100, 1987

    The Japanese Association for Infectious Diseases

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