Pulmonary Histoplasmosis in a Japanese Man Infected During Travel to Mexico and Management of His Wifeʼs Condition：A Case Report

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  • メキシコ渡航中に感染したと推定される肺ヒストプラスマ症の 男性と配偶者への対応
  • 症例 第88回日本感染症学会学術講演会座長推薦論文 メキシコ渡航中に感染したと推定される肺ヒストプラスマ症の男性と配偶者への対応
  • ショウレイ ダイ88カイ ニホン カンセンショウ ガッカイ ガクジュツ コウエンカイ ザチョウ スイセン ロンブン メキシコ トコウ チュウ ニ カンセン シタ ト スイテイ サレル ハイ ヒストプラスマショウ ノ ダンセイ ト ハイグウシャ エ ノ タイオウ

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Abstract

We report herein on the case of a 33-year-old Japanese man in whom an abnormal shadow was detected on chest radiography during a medical checkup after a 1-year-stay in Mexico. Chest computed tomography showed a nodule in the left lower lobe adjacent to the visceral pleura. Histopathologic examination of a thoracoscopic partial pulmonary resection specimen showed coagulation necrosis with a number of yeast-like forms on Grocott staining. In addition, serum anti-Histoplasma antibody positivity was detected with an enzyme-linked immunosorbent assay, and Histoplasma-specific nested real-time polymerase chain reaction results were positive in the pulmonary region. Finally, pulmonary histoplasmosis was diagnosed, and treatment with itraconazole was initiated. The patientʼs wife who had accompanied him to Mexico was asymptomatic and was not found to have histoplasmosis based on diagnostic imaging and serological findings. Although rare in Japan, histoplasmosis should be considered in the differential diagnosis of pulmonary lesions in patients who have returned from travel to endemic areas.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 90 (1), 83-87, 2016

    The Japanese Association for Infectious Diseases

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