Therapeutic Effects of SM-4300, Antibiotics Combinations Against Severe Bacterial Infections in the Field of Surgery

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  • 外科域における重症細菌感染症に対する静注用人免疫グロブリン (SM-4300) と抗生剤との併用効果
  • ゲカイキ ニ オケル ジュウショウ サイキン カンセンショウ ニ タイスル ジ

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Description

A newly developed human immunoglobulin, SM-4300, purified by ion-exchange adsorption, hasbeen studied in the surgical field.<BR>SM-4300 has been evaluated clinically in patients with severe infections in the combined use withthe antibiotics.<BR>1. 153 patients were treated with SM-4300 and evaluated by doctors in charge. Clinical effectswere excellent in 12 cases, good in 44, fair in 39, poor in 34 and unknown in 24.<BR>2. Out of 153 cases 82 were accepted as the evaluable cases by the committee. These cases consistedof septicemia in 13 cases, peritonitis in 29, hepato-biliary tract infections in 14, pneumonia in 7, pulmonary suppuration and pyothorax in 4 and others. The majority of patients (90.3%) had one or moreunderlying diseases.<BR>3. Clinical effects of SM-4300 were excellent in 8 cases (9.8%), good in 37 (45.1%), fair in 21 (25.6%) and poor in 16 (19.5%). The efficacy rate was summarised as 54.9%.<BR>4. 57 strains from 52 cases of clinical isorates were evaluable for bacteriological effects which wereeradicated in 22 strains, decreased in 8 and persisted in 27.<BR>5. No clinical side effects were obserbed.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 58 (12), 1315-1328, 1984

    The Japanese Association for Infectious Diseases

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