百日咳におけるリンパ球増多に関する研究小児における百日咳感染時および百日咳ワクチン接種後の末梢血リンパ球数の変動とそのSubpopulationについて

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書誌事項

タイトル別名
  • Studies on Lymphocytosis associated with Pertussis Infection and Vaccination Analysis of Lymphocyte Subpopulation
  • ヒャクニチゼキ ニ オケル リンパキュウ ゾウタ ニカンスルケンキュウ ショウ

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説明

Children with pertussis infection or vaccination were studied for the lymphocyte count and the subpopulation in the blood at various stages.<BR>Over the period of the 1st four weeks following pertussis infection, the lymphocyte count was twice as high as that of controls (13.46-13.74 × 103/cumm). The absolute numbers of T cells and B cells were also greater than that of controls throughout the study period. The number of B cells reached the highest level of 5.43 × 103/cumm during the first week of illness and decreased gradually thereafter; 4.20 × 103/cumm at the second week, 3.95 × 103/cumm at the third week, 3.71 × 103/cumm at the fourth week and 2.44-103/cumm at the fifth week. T cells continued to increase in number until the fourth week; 7.86 × 103/cumm at the first week, 9.08 × 103/cumm at the second week, 9.62 × 103/cumm at the third week and 9.71 × 103/cumm at the fourth week and then began to decrease, 7.64 × 103/cumm at the fifth week. Accordingly T/B ratio showed a steady increase over the first five weeks (1.45, 2.17, 2.43, 2.62, 3.13).<BR>At 0, 4, 15, 22 and 150 hours following the pertussis vaccination, the number of the lymphocytes was 2.91 × 103/cumm, 4.89 × 103/cumm, 5.47 × 103/cumm, 4.07 × 103/cumm and 3.84 × 103/cumm respectively. T cells continued to increase until 15 hours following the vaccination and then began to decrease gradualyi; 2.06 × 103/cumm before the injection, 3.20 × 103/cumm after 4 hrs, 4.07 × 103/cumm after 15 hrs, 3.07 × 103/cumm after 22 hrs and 2.87 × 103/cumm after 150 hrs. B cells increased promptly after the vaccination and then gradually decreased; 1.92 × 103/cumm, 1.83 × 103/cumm, 1.11 × 103/cumm, 1.03 × 103/cumm. T/B ratio increased steadily until 150 hours after the vaccination; 1.67, 2.23, 2.76, 2.78. Although B cells and T cells remained elevated throughout the study periods, a remarkable increase in the number of B cells was promptly observed following both natural pertussis infection and the vaccination. It appears likely that the early lymphocytosis reflects an increase in the number of B cells.

収録刊行物

  • 感染症学雑誌

    感染症学雑誌 54 (8), 383-395, 1980

    一般社団法人 日本感染症学会

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