Bactericidal Activities of Various Disinfectants in Responce to the Concentration, Period of Exposure and Addition of Blood Serum

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  • 各種消毒薬の作用濃度, 作用時間および血清添加による殺菌効果の変動
  • カクシュ ショウドクヤク ノ サヨウ ノウド サヨウ ジカン オヨビ ケッセイ

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Abstract

Bactericidal activities upon gram-negative bacilli of various disinfectants (phenol, cresol soap, iodophor, benzethonium chloride, chlorhexidine, glutaraldehyde, alkil di (amino ethyl) glycin and triclosan) were examined by a method similar to that for determining the phenol index for the purpose of evaluating fundamentally the effect of disinfectants. The results may be summarized as follows:<BR>On the disinfectants tested, those showing bactericidal effects at the concentration routinely used and upon exposure for one minute or shorter were phenol, cresol soap, iodophor and glutaraldehyde.<BR>Chlorhexidine and benzethonium chloride showed ver y inconsistent bactericidal effects o n gramnegative bacilli by short-time exposure. Many strains were not killed by these agents at concentrations routinely used.<BR>The bactericidal effect of chlorhexidine was enhanced when used in the presence of ethanol.<BR>Addition of blood serum, affecting most largely the effect of iodophor, markedly lowered the bactericidal effect.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 53 (6), 292-303, 1979

    The Japanese Association for Infectious Diseases

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