Comparison of Clinical Efficacy of Pipemidic acid (PPA) and Kanamycin (KM) in Bacillary Dysentery by Double Blind Method

DOI Web Site PubMed

Bibliographic Information

Other Title
  • 細菌性赤痢に対するピペミド酸 (PPA) とカナマイシン (KM) の二重盲検法による治療効果の検討
  • サイキンセイ セキリ ニ タイスル ピペミドサン PPA ト カナマイシン K

Search this article

Description

The efficacy of Pipemidic acid (PPA), a new synthetic antibacterial agent, was compared with that of Kanamycin (KM) for the treatment of bacillary dysentery patients or carriers by a double blind method. PPA and KM were administered in a dosage of 2.0g/day for a period of 5 days respectively. Of 211 cases studied, efficacy was evaluated in 139 cases; 73 received PPA and 66 KM. There was no significant difference between the two groups in terms of the background factors.<BR>The results obtained were as follows:<BR>1) According to the clinical efficacy, the ratio of “excellent plus good” was 86.3% with PPA group and 78.5% with KM group. There was no significant difference between the two groups, while PPA group was found to be significantly superior in patients groups, with PPA group being 92.5% and with KM group being 72.5%.<BR>2) With respect to the efficacy for symptoms as evaluated by the effect on defervascence, disappearance of bloody stool, decrease of number of defecation and improvement in stool character, PPA group was found to be significantly superior to KM group in all of these symptoms but stool character.<BR>3) Effect on bacterial discharge, PPA group was found to be significantly superior to KM group, with PPA group being 95.9% and with KM group being 77.3%.<BR>4) Clinical symptoms as side effects were observed 2 cases in PPA group and 3 cases in KM group.<BR>5) On the MIC of shigellae isolated from clinical cases, peak levels of PPA group was 1.56μg/ml and KM group was 6.25μg/ml.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 57 (4), 303-317, 1983

    The Japanese Association for Infectious Diseases

Keywords

Details 詳細情報について

Report a problem

Back to top