Childhood Bacterial Meningitis Trends in Japan from 2007 to 2008

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  • SUNAKAWA Keisuke
    Kitasato Institute for Life Science & Graduate School of Infection Control Science, Kitasato University
  • SAKAI Fuminori
    Kitasato Institute for Life Science & Graduate School of Infection Control Science, Kitasato University
  • HIRAO Yuriko
    Kitasato Institute for Life Science & Graduate School of Infection Control Science, Kitasato University
  • HANAKI Hideaki
    Kitasato Institute for Life Science & Graduate School of Infection Control Science, Kitasato University
  • NONOYAMA Masato
    Department of Pediatrics, Ebina General Hospital
  • IWATA Satoshi
    Department of Pediatrics, National Hospital Organization Tokyo Medical Center
  • AKITA Hironobu
    <sup> </sup>Department of Pediatrics, St. Marianna University School of Medicine Yokohama City Seibu Hospital
  • SATO Yoshitake
    Department of Pediatrics, Fuji Heavy Industries LTD. Health Insurance Society Genaral Ota Hospital

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Other Title
  • 本邦における小児細菌性髄膜炎の動向（2007～2008）
  • ホンポウ ニ オケル ショウニ サイキンセイ ズイマクエン ノ ドウコウ 2007 2008

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Description

We surveyed pediatrics bacterial meningitis epidemiology from January 2007 to December 2008 in Japan, with the following results : Cases numbered 287-160 male and 127 female-equivalent to 1.54-1.62 of 1,000 pediatric hospitalization per year. Children under 1-year-old accounted for the highest number of cases,which decreased with increasing age. Haemophilus influenzae was the most common cause of infection, followed by Streptococcus pneumoniae, group B streptococcus (GBS), and Escherichia coli. GBS and E. coli were major pathogens in children under 4 months of age, while H. influenzae and S. pneumoniae mainly accounted for those over 4 months of age. Susceptibility tests showed that 51％of H. influenzae isolates and 56.5％of S. pneumoniae isolates in 2008 were drug-resistant. Ampicillin combined with cephem antibiotics effective against GBS, E. coli, and Listeria, were mainly used to initially treat those under 4 months of age. In those over 4 months of age, carbapenem antibiotics are effective against PRSP and cephem antibiotics against H. influenza.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 84 (1), 33-41, 2010

    The Japanese Association for Infectious Diseases

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