Comparative Clinical Trial of HBK and Amikacin (AMK) in the Treatment of Respiratory Infections
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- HARA Kohei
- The Second Department of Internal Medicine, Nagasaki University School of Medicineand Related Hospital
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- SAITO Atsushi
- The Second Department of Internal Medicine, Nagasaki University School of Medicineand Related Hospital
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- YAMAGUCHI Keizo
- The Second Department of Internal Medicine, Nagasaki University School of Medicineand Related Hospital
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- SHIGENO Yoshiteru
- The Second Department of Internal Medicine, Nagasaki University School of Medicineand Related Hospital
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- TAIRA Kazushige
- The Second Department of Internal Medicine, Nagasaki University School of Medicineand Related Hospital
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- ODA Toshiro
- The Second Department of Internal Medicine, Nagasaki University School of Medicineand Related Hospital
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- HAYASHI Toshiaki
- The Second Department of Internal Medicine, Nagasaki University School of Medicineand Related Hospital
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- TOMITA Hiroshi
- The Second Department of Internal Medicine, Nagasaki University School of Medicineand Related Hospital
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- MASUYAMA Yasuharu
- The Second Department of Internal Medicine, Nagasaki University School of Medicineand Related Hospital
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- SAITO Akira
- The Second Department of Internal Medicine, Hokkaido University School of Medicineand Releated Hospital
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- TOMIZAWA Masumi
- The Second Department of Internal Medicine, Hokkaido University School of Medicineand Releated Hospital
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- NAKAYAMA Ichiro
- The Second Department of Internal Medicine, Hokkaido University School of Medicineand Releated Hospital
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- ABE Morikuni
- The Second Department of Internal Medicine, Hokkaido University School of Medicineand Releated Hospital
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- MATSUHASHI Shosei
- The Second Department of Internal Medicine, Hokkaido University School of Medicineand Releated Hospital
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- ISHIKAWA Kiyofumi
- The Second Department of Internal Medicine, Hokkaido University School of Medicineand Releated Hospital
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- UJIIE Akira
- The Second Department of Internal Medicine, Hokkaido University School of Medicineand Releated Hospital
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- NAKABAYASHI Takehito
- Respiratory Division, National Sapporo Hospital
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- KOROKU Tetsuji
- Respiratory Division, National Sapporo Hospital
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- HIRAGA Yohmei
- Department of Respiratory Disease, Sapporo Hospital of Japanese National Railway
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- KIKUCHI Kohki
- Department of Respiratory Disease, Sapporo Hospital of Japanese National Railway
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- YAMAMOTO Asako
- Department of Respiratory Disease, Sapporo Hospital of Japanese National Railway
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- TAKEBE Kazuo
- The Third Department of Internal Medicine, Hirosaki University School of Medicine and Related Hospital
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- OKAMOTO Katsuhiro
- The Third Department of Internal Medicine, Hirosaki University School of Medicine and Related Hospital
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- SAGARA Morio
- The Third Department of Internal Medicine, Hirosaki University School of Medicine and Related Hospital
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- TAMURA Toyokazu
- The Third Department of Internal Medicine, Hirosaki University School of Medicine and Related Hospital
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- ENDO Katsumi
- The Third Department of Internal Medicine, Hirosaki University School of Medicine and Related Hospital
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- IRIE Tatsuro
- The Third Department of Internal Medicine, Hirosaki University School of Medicine and Related Hospital
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- UEHARA Osamu
- The Third Department of Internal Medicine, Hirosaki University School of Medicine and Related Hospital
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- TAMURA Masao
- The Third Department of Internal Medicine, School of Medicine, Iwate Medical University
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- ITO Takashi
- The Third Department of Internal Medicine, School of Medicine, Iwate Medical University
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- OBARA Kazuo
- The Third Department of Internal Medicine, School of Medicine, Iwate Medical University
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- MIYAMOTO Shinya
- The Third Department of Internal Medicine, School of Medicine, Iwate Medical University
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- KANAZAWA Tomohiro
- The Second Department of Internal Medicine, Akita University School of Medicine
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- TAKAHASHI Hiroshi
- The Second Department of Internal Medicine, Akita University School of Medicine
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- 三浦 一樹
- 秋田大学第2内科
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- KUROKAWA Hirokazu
- The Second Department of Internal Medicine, Akita University School of Medicine
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- YASUI Shoji
- The First Department of Internal Medicine, Yamagata University School of Medicine
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- TAKAHASHI Keiji
- The First Department of Internal Medicine, Yamagata University School of Medicine
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- SATO Shinobu
- The First Department of Internal Medicine, Yamagata University School of Medicine
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- IKEDA Hideki
- The First Department of Internal Medicine, Yamagata University School of Medicine
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- NAKAMURA Hidenori
- The First Department of Internal Medicine, Yamagata University School of Medicine
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- YASUMURA Seiji
- The First Department of Internal Medicine, Yamagata University School of Medicine
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- IGARASHI Kohichi
- The First Department of Internal Medicine, Yamagata University School of Medicine
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- HOSHI Hikaru
- The First Department of Internal Medicine, Yamagata University School of Medicine
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- YAKUWA Sunao
- The First Department of Internal Medicine, Yamagata University School of Medicine
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- TAKISHIMA Tamotsu
- The First Department of Internal Medicine, Tohoku University School of Medicine
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- IDA Shiroh
- The First Department of Internal Medicine, Tohoku University School of Medicine
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- KONNO Kiyoshi
- Department of Internal Medicine, The Research Institute for Chest Diseases and Cancer, Tohoku University and Related Hospital
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- OIZUMI Kotaro
- Department of Internal Medicine, The Research Institute for Chest Diseases and Cancer, Tohoku University and Related Hospital
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- AONUMA Seiichi
- Department of Internal Medicine, The Research Institute for Chest Diseases and Cancer, Tohoku University and Related Hospital
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- WATANABE Akira
- Department of Internal Medicine, The Research Institute for Chest Diseases and Cancer, Tohoku University and Related Hospital
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- NAGAI Kosaku
- Department of Internal Medicine, The Research Institute for Chest Diseases and Cancer, Tohoku University and Related Hospital
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- SATO Kazuo
- Department of Internal Medicine, The Research Institute for Chest Diseases and Cancer, Tohoku University and Related Hospital
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- HAYASHI Izumi
- Division of Respiratory Diseases, Iwaki Kyoritsu General Hospital
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- KATSU Masataka
- Department of Internal Medicine, Kasumigaura National Hospital Department of Internal Medicine, Jiseikai Hospital
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- KAWAI Mieko
- Department of Internal Medicine, Kasumigaura National Hospital Department of Internal Medicine, Jiseikai Hospital
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- OGIWARA Koji
- Department of Internal Medicine, Kasumigaura National Hospital Department of Internal Medicine, Jiseikai Hospital
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- KAWAI Takeshi
- Department of Internal Medicine, School of Medicine, Keio University
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- AJISAWA Atsushi
- Department of Internal Medicine, School of Medicine, Keio University
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- SATO Shigeaki
- The Second Department of Internal Medicine, The Jikei University School of Medicine
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- ISHIKAWA Kazuhito
- The Second Department of Internal Medicine, The Jikei University School of Medicine
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- MIYAHARA Tadashi
- The Second Department of Internal Medicine, The Jikei University School of Medicine
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- IKEMOTO Hideo
- Department of Internal Medicine, Juntendo University School of Medicine
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- WATANABE Kazuyoshi
- Department of Internal Medicine, Juntendo University School of Medicine
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- ISONUMA Hiroshi
- Department of Internal Medicine, Juntendo University School of Medicine
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- KOBAYASHI Hiroyuki
- The First Department of Internal Medicine, Kyorin University School of Medicine
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- KAWAI Shin
- The First Department of Internal Medicine, Kyorin University School of Medicine
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- YOSHIDA Masahiko
- The First Department of Internal Medicine, Kyorin University School of Medicine
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- KUNII Otohiko
- The Second Department of Internal Medicine, Teikyo University School of Medicine
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- MASHIMO Keimei
- Department of Internal Medicine, Tokyo Koseinenkin Hospital
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- YAMANE Yoshiji
- Department of Internal Medicine, Tokyo Koseinenkin Hospital
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- UKAI Tetsuro
- Department of Internal Medicine, Tokyo Koseinenkin Hospital
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- KOYAMA Masaru
- Department of Internal Medicine, Tokyo Kyosai Hospital
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- IIJIMA Fukuo
- Department of Internal Medicine, Tokyo Kyosai Hospital
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- KABE Junzaburo
- Department of Chest Medicine, National Medical Center Hospital
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- ISHIBASHI Hiroyoshi
- Department of Chest Medicine, National Medical Center Hospital
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- UNO Yuko
- Department of Chest Medicine, National Medical Center Hospital
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- TANIMOTO Hiroichi
- Chest Clinic, Toranomon Hospital
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- CHONABAYASHI Naohiko
- Chest Clinic, Toranomon Hospital
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- NAKAMORI Yoshitaka
- Chest Clinic, Toranomon Hospital
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- YOSHIMURA Kunihiko
- Chest Clinic, Toranomon Hospital
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- NAKATANI Tatsuo
- Chest Clinic, Toranomon Hospital
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- NAKATA Koichiro
- Chest Clinic, Toranomon Hospital
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- MASUDA Gohta
- Department of Infectious Diseases, Tokyo Metropolitan Komagome Hospital
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- NEGISHI Masayoshi
- Department of Infectious Diseases, Tokyo Metropolitan Komagome Hospital
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- YOUNG Chenden
- Department of Infectious Diseases, Tokyo Metropolitan Komagome Hospital
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- HIGASHI Fuyuhiko
- Department of Internal Medicine, Hospital of Tokyo Electric Power Co., Inc.
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- FUNATSU Yuzo
- Department of Internal Medicine, Hospital of Tokyo Electric Power Co., Inc.
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- FUJIMORI Ippei
- Department of Internal Medicine, Kawasaki Municipal Hospital
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- KOBAYASHI Yoshio
- Department of Internal Medicine, Kawasaki Municipal Hospital
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- OKUBO Takao
- The First Department of Internal Medicine, Yokohama City University School of Medicine
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- ITO Akira
- The First Department of Internal Medicine, Yokohama City University School of Medicine
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- SANO Fumihiko
- The First Department of Internal Medicine, Yokohama City University School of Medicine
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- MATSUZAKI Michio
- The First Department of Internal Medicine, Yokohama City University School of Medicine
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- ASADA Yuko
- The First Department of Internal Medicine, Yokohama City University School of Medicine
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- ODAGIRI Shigeki
- Department of Respiratory Disease, Kanagawa Prefectural Nagahama Hospital
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- SUZUKI Kaneo
- Department of Respiratory Disease, Kanagawa Prefectural Nagahama Hospital
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- MUROHASHI Kou
- Department of Respiratory Disease, Kanagawa Prefectural Nagahama Hospital
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- FUKUDA Tsutomu
- Department of Respiratory Disease, Kanagawa Prefectural Nagahama Hospital
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- YOSHIIKE Yasuhiro
- Department of Respiratory Disease, Kanagawa Prefectural Nagahama Hospital
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- MATSUMURA Masanori
- Department of Respiratory Disease, Kanagawa Prefectural Nagahama Hospital
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- KIUCHI Mitsuyo
- Department of Respiratory Disease, Kanagawa Prefectural Nagahama Hospital
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- MATSUMOTO Fumio
- Department of Internal Medicine, Kanagawa Prefecture Midwives and Nurses Training School Hospital
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- FUKAYA Kazufuto
- Department of Internal Medicine, Yokohama Teishin Hospital
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- TAKIGAMI Tadashi
- Department of Internal Medicine, Yokohama Seamen's Insurance Hospital
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- SHODA Masataka
- Department of Internal Medicine, Yokohama Seamen's Insurance Hospital
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- ARAKAWA Masaaki
- The Second Department of Internal Medicine, Niigata University School of Medicine
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- WADA Kohichi
- The Second Department of Internal Medicine, Niigata University School of Medicine
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- SEKINE Osamu
- Department of Internal Medicine, Shinrakuen Hospital
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- AOKI Nobuki
- Department of Internal Medicine, Shinrakuen Hospital
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- OYAMA Kaoru
- Department of Internal Medicine, Toyama Prefectural Center Hospital
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- NAKAMURA Shinobu
- The Third Department of Internal Medicine, Kanazawa University School of Medicine and Related Hospital
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- NAKAMURA Takeshi
- The Third Department of Internal Medicine, Kanazawa University School of Medicine and Related Hospital
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- YAMAMOTO Toshiyuki
- Department of Internal Medicine, Nagoya Koseiin Geriatric Hospital
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- SUZUKI Kanzo
- Department of Internal Medicine, Nagoya Koseiin Geriatric Hospital
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- ADACHI Akira
- Department of Internal Medicine, Nagoya Koseiin Geriatric Hospital
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- KUZE Fumiyuki
- The First Department of Internal Medicine, Chest Disease Research Institute, Kyoto University and Related Hospital
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- NAKANISHI Michiyasu
- The First Department of Internal Medicine, Chest Disease Research Institute, Kyoto University and Related Hospital
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- KURASAWA Takuya
- The First Department of Internal Medicine, Chest Disease Research Institute, Kyoto University and Related Hospital
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- KUBO Yoshiro
- The First Department of Internal Medicine, Chest Disease Research Institute, Kyoto University and Related Hospital
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- NISHIYAMA Hideki
- The First Department of Internal Medicine, Chest Disease Research Institute, Kyoto University and Related Hospital
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- IKEDA Nobuaki
- The First Department of Internal Medicine, Chest Disease Research Institute, Kyoto University and Related Hospital
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- INABA Norio
- The First Department of Internal Medicine, Chest Disease Research Institute, Kyoto University and Related Hospital
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- KAGIOKA Akira
- The First Department of Internal Medicine, Chest Disease Research Institute, Kyoto University and Related Hospital
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- MIKI Fumio
- Department of Internal Medicine, Tane General Hospital and Izumi Municipal Hospital
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- IKUNO Yoshiyasu
- Department of Internal Medicine, Tane General Hospital and Izumi Municipal Hospital
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- INOUE Eiji
- Department of Internal Medicine, Tane General Hospital and Izumi Municipal Hospital
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- MURATA Akihito
- Department of Internal Medicine, Tane General Hospital and Izumi Municipal Hospital
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- TANIZAWA Shin-ichi
- Department of Internal Medicine, Tane General Hospital and Izumi Municipal Hospital
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- SAKAMOTO Kazuo
- Department of Internal Medicine, Tane General Hospital and Izumi Municipal Hospital
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- TAKAMATSU Kenji
- Department of Internal Medicine, Tane General Hospital and Izumi Municipal Hospital
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- SOEJIMA Rinzo
- Department of Respiratory Diseases of Internal Medicine, Kawasaki Medical School
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- NIKI Yoshihito
- Department of Respiratory Diseases of Internal Medicine, Kawasaki Medical School
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- HINO Jiro
- Department of Respiratory Diseases of Internal Medicine, Kawasaki Medical School
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- NAKAGAWA Yoshihisa
- Department of Respiratory Diseases of Internal Medicine, Kawasaki Medical School
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- NISHIMOTO Yukio
- The Second Department of Internal Medicine, Hiroshima University School of Medicine
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- YAMAKIDO Michio
- The Second Department of Internal Medicine, Hiroshima University School of Medicine
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- KAMITSUNA Akimitsu
- The Second Department of Internal Medicine, Hiroshima University School of Medicine
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- HASEGAWA Kenji
- The Second Department of Internal Medicine, Hiroshima University School of Medicine
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- KURIMURA Osamu
- Department of Internal Medicine, Kure National Hospital
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- SASAKI Hideo
- Department of Internal Medicine, Kure National Hospital
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- FUKUHARA Hirofumi
- Department of Internal Medicine, Kure National Hospital
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- TAMURA Masakazu
- The Third Department of Internal Medicine, Tokushima University School of Medicine
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- TSUBURA Eiro
- Department of Internal Medicine, The National Toneyama Chest Hospital
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- FUKUYAMA Koichi
- Department of Internal Medicine, The National Toneyama Chest Hospital
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- MORIMOTO Tadaaki
- Department of Internal Medicine, The National Toneyama Chest Hospital
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- SAWAE Yoshiro
- The First Department of Internal Medicine, Faculty of Medicine, Kyushu University
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- NAGANO Hitoshi
- Department of Clinical Research, National Minamifukuoka Chest Hospital
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- YOKOTA Takeo
- Department of Clinical Research, National Minamifukuoka Chest Hospital
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- YOKOTA Kinji
- Department of Clinical Research, National Minamifukuoka Chest Hospital
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- SHINODA Atsushi
- Department of Internal Medicine, National Ohmuta Hospital
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- ISHIBASHI Tsuneo
- Department of Internal Medicine, National Ohmuta Hospital
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- TAKAMOTO Masahiro
- Department of Internal Medicine, National Ohmuta Hospital
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- HARADA Yasuko
- Department of Internal Medicine, National Ohmuta Hospital
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- KITAHARA Yoshinari
- Department of Internal Medicine, National Ohmuta Hospital
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- KAJI Masaro
- The First Department of Internal Medicine, Kurume University School of Medicine
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- ICHIKAWA Yoichiro
- The First Department of Internal Medicine, Kurume University School of Medicine
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- NASU Masaru
- The Second Department of Internal Medicine, Medical College of Oita
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- GOTO Jun
- The Second Department of Internal Medicine, Medical College of Oita
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- GOTO Yoichiro
- The Second Department of Internal Medicine, Medical College of Oita
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- YAMAZAKI Hitoshi
- The Second Department of Internal Medicine, Medical College of Oita
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- TASHIRO Takayoshi
- The Second Department of Internal Medicine, Medical College of Oita
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- MATSUMOTO Keizo
- Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University and Related Hospital
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- OHISHI Kazunori
- Department of Internal Medicine, Institute for Tropical Medicine, Nagasaki University and Related Hospital
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- IZUMIKAWA Kinichi
- Department of Internal Medicine, Sasebo Municipal Hospital
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- KOTEDA Tsunetoshi
- Department of Internal Medicine, Sasebo Municipal Hospital
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- NAKAJIMA Manabu
- Department of Internal Medicine, Sasebo Municipal Hospital
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- KOMATSU Kohei
- Department of Internal Medicine, Sasebo Municipal Hospital
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- NAKATA Masaya
- Department of Internal Medicine, Sasebo Municipal Hospital
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- SENJU Reiko
- Department of Internal Medicine, Sasebo Municipal Hospital
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- ANDO Masayuki
- The First Department of Internal Medicine, Kumamoto University School of Medicine
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- SUGA Moritaka
- The First Department of Internal Medicine, Kumamoto University School of Medicine
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- NIIBORI Toshifumi
- The First Department of Internal Medicine, Kumamoto University School of Medicine
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- NAKAGAWA Toshiyuki
- The First Department of Internal Medicine, Kumamoto University School of Medicine
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- YOSHIDA Kazuko
- The First Department of Internal Medicine, Kumamoto University School of Medicine
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- KOBARI Kazumine
- The First Department of Internal Medicine, Ryukyu University School of Medicine
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- NAKATOMI Masao
- The First Department of Internal Medicine, Ryukyu University School of Medicine
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- TANAKA Tsuneo
- Faculty of Medicine, University of Tokyo
Bibliographic Information
- Other Title
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- 呼吸器感染症に対するHBKとAmikacinの薬効比較成績
- 呼吸器感染症に対するHBKとAmiracinの薬効比較成績
- コキュウキ カンセンショウ ニ タイスル HBK ト Amiracin ノ ヤッコウ ヒカク セイセキ
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Abstract
The clinical efficacy and safety of HBK were compaired with those of amikacin (AMK) in 230 patients with respiratory infections (pneumonia or lung abscess, chronic respiratory tract infections) by means of a double-blind study at 50 institutions in Japan. Patients over 15 years old with apparent clinical signs and symptoms were administered HBK or AMK intramuscularly b. i. d. for 14 days with a daily dose of 200 mg (pot.) of HBK or 400 mg (pot.) of AMK. The parameters assessed were clinical efficacy, rate of improvement of clinical signs and symptoms, bacteriological response, appearance of side effect, abnormal laboratory findings and clinical usefulness.<BR>Clinical efficacy was analysed statistically in 199 patients (100 administered HBK, 99 administered AMK), but 31 patients out of a total of 230 patients were excluded. Side effects were also anlaysed in 213 patients (HBK: 108, AMK: 105) in whom judgement was possible.<BR>1. On the basis of committee judgement, the overall clinical efficacy rate for pneumonia or lungabscess was 63.2% for HBK and 69.4% for AMK. Those for chronic respiratory tract infections were 46.5% for HBK and 60.0% for AMK. No significant difference was observed between the two drug groups.<BR>In the evaluation of clinical efficacy by the doctor, the overall efficacy ratesinpneumonia or lung abscess cases were 70.4% for HBK and 61.2% for AMK. Those for chronic respiratory tract infections were 55.8% for HBK and 62.0% for AMK. No significant difference was observed between the two drug groups.<BR>2. With respect to the rate of improvement of clinical signs and symptoms, the HBKgroup was superior to the AMK group in the improvement of sputum volume five days after treatment (p<0.05) in patients with pneumonia or lung abscess. In patients with chronic respiratory tract infections, the AMK group was superior to the HBK group in the improvement of body temperature and CRPseven days after treatment (p<0.05).<BR>3. The bacteriological eradication rate of causative organisms was 38.3% out of 51 patients treated with HBK and 37.5% out of 50 treated with AMK. There was no significant differencebetween the two groups.<BR>4. Some side effects were observed in 10 patients out of 108 in the HBK group, butnone were observed in the AMK group. The HBK group displayed a significantly higher rate of side effects than the AMK group. Abnormal laboratory findings were observed at the rate of 23.4% forHBK and 20.0% for AMK, without significant differences between the two groups.<BR>5. Regarding usefulness as judged by committee members, the respective rate for the HBK group and AMK group were 53.8% and 64.6%. Usefulness, as judged by the doctor in charge, was 63.0% for the HBK group and 63.3% for the AMK group. These assessments showed no significantdifferences between the two groups.<BR>From the above results, it was concluded that HBK is as equally useful as AMK for the drug treatment of respiratory infections.
Journal
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- Kansenshogaku Zasshi
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Kansenshogaku Zasshi 61 (1), 22-53, 1987
The Japanese Association for Infectious Diseases
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Details 詳細情報について
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- CRID
- 1390001205050045312
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- NII Article ID
- 130004329213
- 40000566515
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- NII Book ID
- AN00047715
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- ISSN
- 1884569X
- 03875911
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- NDL BIB ID
- 3123331
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- PubMed
- 3106530
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed