In Vitro Evaluation of Antimicrobials Removal with Adsorbens

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  • OKUDA Shinichiro
    The Second Department of Internal Medicine, Jikei University School of Medicine
  • SAITO Atsushi
    The Second Department of Internal Medicine, Jikei University School of Medicine
  • MIYAHARA Tadashi
    The Second Department of Internal Medicine, Jikei University School of Medicine
  • WATANABE Kunitomo
    Institute of Anaerobic Bacteriology, Gifu University School of Medicine
  • UENO Kazue
    Institute of Anaerobic Bacteriology, Gifu University School of Medicine

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Other Title
  • 吸着体による抗菌剤の除去に関する基礎的検討
  • キュウチャクタイ ニ ヨル コウキンザイ ノ ジョキョ ニ カンスル キソテキ

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Description

We examined about removal of antimicrobials in blood samples.<BR>First, the Antimicrobial Removal Divice (ARD: Marion Laboratories, Inc., Kansas City, Mo.) and two kinds of charcoals (uncoated activated charcoal “yashigaratan” and cellulose coated activated charcoal “biizutan”) were evaluated in vitro with samples of 15 antimicrobials.<BR>In addition, we checked both difference of ifs ability to remove by cell number in samples and adverse effect on organisms.<BR>And the following results were obtained.<BR>1. The ARD revealed much effectiveness in reducing the activity of all 15 antimicrobials, but it seems to suggest that effectiveness of ARD was not enough in the case that antibacterial activity of the drugs after ARD processing is higher than MIC of the organisms or cell number in samples are less.<BR>2. Uncoated activated charcoal wass more effective than ARD on removal of antimicrobials except Aminoglycosides and PPA, but cellulose coated activated charcoal had no effect on all.<BR>3. There was no adverse effect of the ARD on organisms, but cell number in samples decreased after treatment of charcoal especially uncoated activated charcoal.<BR>These results seem to suggest that the ARD was the only system to actually use and improved use of charcoal can be useful in the clinical microbiology laboratory.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 59 (11), 1073-1083, 1985

    The Japanese Association for Infectious Diseases

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