The Investigation of Prostatic Fluid and Tissue Levels of DL-8280 and Clinical Study of DL-8280 in Acute Prostatitis

HARA Sanshin, NAKASU Hazime

doi:10.11150/kansenshogakuzasshi1970.58.921

The concentration of DL-8280, a new oral antibacterial agent, in prostatic fluid and tissue was determined, and based on this result, DL-8280 was administered to the patients with acute prostatitis.<BR>For the determination of prostatic fluid levels of DL-8280, 300mg of DL-8280 was administered orally to 6 male healthy volunteers, three were the twenties and three were the fifties. Prostatic fluid was obtained by prostate massage at 1, 2 and 3 hours after dosing in the twenties and at 2 hours after dosing in the fifties. The prostatic fluid levels of DL-8280 in the twenties occurred a little later comparing with serum levels and the average level at 3 hours after administration was 1.82μg/ml. The prostatic fluid level of DL-8280 in the fifties was 2.78μg/ml at 2 hours after dosing and that of the twenties was 1.50μg/ml.<BR>The concentration of DL-8280 in prostatic tissue was determined with the sample obtained by transurethral resection prostatectomy (TUR-P) from the patients with benign prostatic hyperplasia who were given 300g of DL-8280 orally before the operation. The prostatic tissue levels of 2-3μg/g was obtained correlatively with serum levels at 1, 2 and 3 hours after dosing.<BR>Since these results showed a possible efficacy of DL-8280 on bacterial prostatitis, 9 patients of acute prostatitis were administered DL-8280 orally. The efficacy rate was 80%, 100% and 100% at Evaluation on Day 3 (5 patients), on Day 7 (9 patients) and on Day 14 (7 patients), respectively.<BR>Transient rash was observed in one patient as a side effect.

The Investigation of Prostatic Fluid and Tissue Levels of DL-8280 and Clinical Study of DL-8280 in Acute Prostatitis

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