緑膿菌感染防禦に関する研究特にOEP特異抗体を指標として-その1OEP特異IgG, IgM抗体のマクロファージ緑膿菌食菌能に及ぼす影響について

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タイトル別名
  • The Influence of Anti-OEP-IgG and-IgM upon Mouce Spleen Macrophage-Phagocytic Activity against Pseudomonas aeruginosa and OEP-coated Latex Glanules
  • 緑濃菌感染防禦に関する研究--特にOEP特異抗体を指標として-1-OEP特異IgG,IgM抗体のマクロファージ緑濃菌食菌能に及ぼす影響について
  • リョクノウキン カンセン ボウギョ ニカンスルケンキュウ トクニ OEP トク

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A large role in the defence mechanism against bacterial infection is attributed to the phagocytic reaction of white blood cells.<BR>We reported that anti-OEP-IgG was effective against the experimental Pseudomonas aerugionosa infection in mice, even when in the immunosuppressive stage. At the same time, large monocytes in spleen were observed ingesting many bacteria.<BR>Unfortunately, however, almost all of the antibody produced againt Gram-negative bacteria is in the IgM fraction of blood serum, so, it is very difficult to use for therapy in humans.<BR>Recently, we observed occasionally that anti-OEP-IgG was contained in the commercial gammaglobulin products, although its titer was not so high.<BR>The following experiments wer attemped to reveal (1) whether it was clinically feasible to use this anti-OEP-IgG in such a low titer, (2) the relationship between the marcophage, the anti-OEP-globulins and the bacteria in the activity observed. (3) whether the macrophage's phagocytic reaction to P. aeruginosa was affected more strongly by IgG or by IgM. (4) the difference of the macrophage's phagocytic reaction against P. aeruginosa versus the OEP-coated Latex Particles; this was donein order to reveal the mechanisms of P. aeruginosa's anti-phagocytic nature if there was a synergistic effect when using egntamicin together with the immunotherapy.<BR>The antibody significantly enhanced the macrophage's phagocytosis against P. aeruginosa, also the IgG fraction had stron ger activitythan the IgM fraction. By addition of gentamicin, the phagocytic reactions were significantly strengthend statistically. There was no signifficant difference in the phagocytic activity against either P. aeruginosa or the Latex particle. The adhesive reaction between the antibodies and the bacteria was remarkable but not between the antibody and the macrophage. Also, the adhesive reaction between the atibody and the bacteria was enhanced by gentamicin. The activity of the IgG was stronger thanthat of the IgM, too. All the experiments were performed within the clinically accepted doses for anti-OEP-IgG and gentamicin.

収録刊行物

  • 感染症学雑誌

    感染症学雑誌 52 (11), 482-489, 1978

    一般社団法人 日本感染症学会

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