書誌事項
- タイトル別名
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- Pseudomembranous Colitis due to Clostridium <I>difficile</I> and the New Therapeutic Approach
- Clostridium difficileの分離された偽膜性腸炎の1例とその治療について
- Clostridium difficile ノ ブンリサレタ ギマクセイ チョ
- Pseudomembranous Colitis due to Clostridium difficile and the New Therapeutic Approach
この論文をさがす
抄録
A case of pseudomembranous colitis due to Clostridium difficile and the new th erapeutic approach.<BR>A 5 year 7 months old Japanese girl has been in good health untile 5 days before admission when she started to complain of abdominal pain, high fever, vomiting and generalized convulsion. The initial clinical impression was septicemia. She was given ampicillin 100 mg/kg and gentamycin 5 mg/kg. On the 5th hospital day severe colic and watery stools with blo od developed. The leukocytecount was 15, 400/cmm with 90% neutrophiles. The hemoglobin was 10.4 g/dl, serum protain 3.8 g/dl and albumin 1.99 g/dl. Blood and albumin transfusions were performed but the hypoalb uminemia and anemia persisted. The Gordon test was 2.8%. An X-ray film of the abdomen showed thumbprinting, and a scintigram of abdomen ruled out hemorrhagc gastroduodenitis and Meckel's diverticulitis. The proctosigmoidoscopy revealed an edemato us mucosa with white-yellow plaques indicating PMC. Administration of antibiotics was stopped. The plasma FDP was above 40 μg/ml and the thrombocyte count remained 30.5 × 104/cmm. The plasma factor XIII level was 42%, but the plasma plasmin activity, fibrinogen, bleeding time, coagulation time were normal<BR>A total of 1250 units (5 vials) of factor XIII concentrate (Behringwe rke-Hoechst) was administered in 3 days. The abdominal pains subsided and the bowel movement became normal.<BR>Clostridium difficile of over 108/g were found in the stool on the 7th hospital day. Heat labile enterotoxin to the mouse Y-1 adrenal cell was also demonstrated<BR>These results suggests that treatment with factor XIII offers a new possibility of controlling severe hemorrhagic diarrhea in antibiotics-associated PMC.
収録刊行物
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- 感染症学雑誌
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感染症学雑誌 54 (9), 518-524, 1980
一般社団法人 日本感染症学会
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詳細情報 詳細情報について
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- CRID
- 1390001205050950784
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- NII論文ID
- 130004328663
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- NII書誌ID
- AN00047715
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- COI
- 1:STN:280:DyaL3M3hs1ynsA%3D%3D
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- ISSN
- 1884569X
- 03875911
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- NDL書誌ID
- 2223650
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- PubMed
- 6787148
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可