Experimental Urinary Tract Infection in Mice to Evaluate the Pathogenicity of <I>Escherichia coli</I>

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  • KAKUNO Yoichi
    Faculty of Hygiene, College of Environmental Health, Azabu University
  • HONDA Masayuki
    Faculty of Hygiene, College of Environmental Health, Azabu University
  • TAKAKURA Koji
    Faculty of Hygiene, College of Environmental Health, Azabu University

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Other Title
  • マウス実験的尿路感染症による大腸菌の尿路病原性の評価
  • マウス ジッケンテキ ニョウ ミチ カンセンショウ ニ ヨル ダイチョウキン
  • Experimental Urinary Tract Infection in Mice to Evaluate the Pathogenicity of Escherichia coli

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Abstract

We studied an experimental urinary tract infection in mice with 30 strains of Escherichia coli to know whether the strains isolated from urine of patients with urinary tract infections are more vilulent on the urinary tract than the strains isolated from feces. Mice were transurethrally inoculated with 1×107bacteria, and given no additional treatment. The bacteria were recovered from 50% of the kidneys.<BR>Common O serogroups in the infection caused inflammatory responses not more severely than the other serogroups did. Pathogenecity of these bacteria may be too weak to be detected by the experimental infection in animals with normal condition.<BR>On the other hand, the strains isolated from urine of patients, however, were recovered more frequently and densely from the kidneys of mice than the strains from feces (p<0.01). Thus, we concluded that the strains causing urinary tract infections are not mere opportunistsbut have some affinity for the tracts.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 60 (7), 666-672, 1986

    The Japanese Association for Infectious Diseases

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