抗生剤経口投与の腸内細菌叢に及ぼす影響

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書誌事項

タイトル別名
  • Relationship between the Intestinal Flora and the Urinary Tract Infection
  • 抗生剤経口投与の腸内細菌叢に及ぼす影響-2-腸内細菌叢の変動と尿路感染症
  • コウセイザイ ケイコウ トウヨ ノ チョウナイ サイキンソウ ニ オヨボス エ
  • 第二編腸内細菌叢の変動と尿路感染症

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抄録

ABPC, ACPC, CEX and EM were orally administered to children suffering from infectious diseases and effects of each antibiotic on intestinal bacteria were investigated; in other words, the fluctuations of bacteria in stool and the nature of stool were examined. Also, the relation between the microbisme sélectionné et substitutée in urinary tract infections and the fluctuations of bacteria in stool by oral administration of antibiotics was investigated. The following are the results of our studies:<BR>1) The highest frequency of diarrhoea was caused by administration of ABPC; loose stool, nausea and discomfort at the stomach were recognized in the case of EM administration and almost no symptom was discovered at the digestive organs by administration of either of ACPC and CEX.<BR>2) The fluctuations of bacteria in stool were found as follows: by administration of ABPC, E. coli and Streptococcus decreased, Klebsiella increased and Bacteroides decreased; by ACPC, almost no fluctuations were recognized; by CEX, a decrease in E. coli and no change in Streptococcus meaning a correlative increase of Streptococcus against E. coli, and an increase in Enterobacter were recognized; by EM administration, E. coli and Streptococcus decreased while Bacteroides, Lactobacillus and Peptostreptococcus decreased remarkably.<BR>3) When ABPC or CEX is administered orally to patients suffering from urinary tract infections, the following microbisme sélectionné et substituté must be taken into consideration: in the case of ABPC, a change-over of bacteria to Klebsiella, and in that of CEX, to Enterobacter, Streptococcus and/or Pseudomonas. The above phenomena correlate to the fluctuations of the number of organisms in stool.<BR>4) Urinary tract infections during the baby and infant years often cause recurrences and are likely to become chronic, which may eventually result in dysfunction of the renal parenchyma. Therefore, antibiotics must be administered very carefully to the above-described patients and it seems preferable to administer such an agent intravenously rather than orally.

収録刊行物

  • 感染症学雑誌

    感染症学雑誌 54 (12), 780-788, 1980

    一般社団法人 日本感染症学会

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