Effect against Macrophage of Purified SPA of <I>S. enteritidis</I>

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  • <I>Salmonella enteritidis</I> SPA のマクロファージに対する影響
  • Salmonella enteritidis SPAのマクロファージに対する影響
  • Salmonella enteritidis SPA ノ マクロファージ ニ
  • Effect against Macrophage of Purified SPA of S. enteritidis

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Description

When Lipopolysaccharide (LPS), Muramyl dipeptide (MDP) were injected intraperitoneally in mice, the number of macrophages, neutrophils and lymphocytes in peritoneal cavity, blood and spleen reached a maximum until 10 days. While Soluble Protective Antigen (SPA) were injected intraperitoneally in mice, those reached a maximum at 14 days. This corresponded that the protective activity of SPA reached a maximum at 14 days. The phagocytic activity against Latex beads of macrophages treated with SPA was higher than that of LPS, MDP. And even 30 days after of SPA treatment, a significant increase of phagocytic activity was evident as compared to control. The production of lysozome enzyme (Cathepsin-D, Acid-phosphatase, β-N-Acetyl-D-glucosaminidase, Lysozyme) and NBT reduction activity in macrophages treated with SPA increased as compared to control.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 60 (5), 485-494, 1986

    The Japanese Association for Infectious Diseases

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