Genetic Analysis of Multidrug-resistant <i>Streptococcus pneumoniae </i>Including Meropenem Resistance that was Isolated from Elderly Residents with Pneumonia in Nursing-care Facilities

DOI Web Site Web Site 1 Citations 9 References
  • OTA Kazuko
    Department of Clinical Laboratory, Odate Municipal Hospital
  • CHIBA Naoko
    Laboratory of Molecular Epidemiology for Infectious Agents, Kitasato Institute for Life Sciences, Kitasato University,（Present Affiliation : Department of Infectious Diseases, Keio University School of Medicine）
  • SATO Kentaro
    Department of Clinical Laboratory, Odate Municipal Hospital
  • NARA Syoetu
    Department of Clinical Laboratory, Odate Municipal Hospital
  • KATO Satoko
    Department of Pharmacy, Odate Municipal Hospital
  • KANAZAWA Hisao
    Department of Pharmacy, Odate Municipal Hospital
  • IKEJIMA Shin
    Department of Internal Medicine, Odate Municipal Hospital
  • TAKAHASHI Yoshihiro
    Infection Control and Prevention Division, Department of Clinical Labora tory, Odate Municipal Hospital
  • IWATA Satoshi
    Department of Infectious Diseases, Keio University School of Medicine
  • UBUKATA Kimiko
    Laboratory of Molecular Epidemiology for Infectious Agents, Kitasato Institute for Life Sciences, Kitasato University,（Present Affiliation : Department of Infectious Diseases, Keio University School of Medicine）

Bibliographic Information

Other Title
  • 介護施設入所の高齢者肺炎例から分離されたMeropenem 耐性を 含む多剤耐性肺炎球菌の遺伝子学的解析
  • カイゴシセツ ニュウショ ノ コウレイシャ ハイエンレイ カラ ブンリ サレタ Meropenem タイセイ オ フクム タザイ タイセイ ハイエン キュウキン ノ イデンシガクテキ カイセキ
  • Genetic analysis of multidrug-resistant Streptococcus pneumoniae including meropenem resistance that was isolated from elderly residents with pneumonia in nursing-care facilities

Search this article

Abstract

From February to December 20XX, penicillin-resistant Streptococcus pneumoniae (PRSP) showing MICs of 16-32μg/mL to cefotaxime (CTX) and 4-8μg/mL to meropenem (MEPM) were isolated from 6 patients hospitalized at the general hospital S (2 cases) and hospital A (4 cases), close to the hospital S. Five elderly patients among these six cases came from nursing care facilities or nursing care-related medical facilities. All elderly persons (mean age : 81.7 years) were diagnosed as having pneumonia at the time of admission and the problematic PRSP was isolated from sputum samples collected on admission. Notably, all of these PRSP isolates simultaneously showed high resistance to macrolide agents mediated by an erm (B) gene and to fluoroquinolone agents via mutations in the gyrA and parC genes. Eventually, they were identified as multidrug-resistant S. pneumoniae (MDRSP) with high resistance to many agents. The capsule type of all strains was serotype 19F and multilocus sequence typing (MLST) revealed that they belonged to clonal complex (CC) 7993, which has not been reported before. It was thus concluded that the MDRSP that had spread within the nursing facilities was transmitted to the general hospitals via the elderly inpatients with pneumonia caused by these agents. Although one case finally had a poor outcome, the pneumococcal infection was not the direct trigger of the event. The current ratio of MDRSP is concluded to be very low. However, general hospitals that accept patients for therapeutic purposes from nursing-care facilities have to share epidemiological information in a timely manner with the nursing homes to prevent nosocomial infections.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 88 (4), 444-451, 2014

    The Japanese Association for Infectious Diseases

Citations (1)*help

See more

References(9)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top