Analysis of Prevalent <I>Orientia tsutsugamushi</I> in Aichi Prefecture

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Other Title
  • 愛知県のつつが虫病リケッチア流行株の解明
  • アイチケン ノ ツツガムシビョウ リケッチア リュウコウカブ ノ カイメイ
  • Analysis of Prevalent Orientia tsutsugamushi in Aichi Prefecture

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Abstract

Orientia tsutsugamushi was isolated from one of 8 patients' sera in Aichi Prefecture, and was identified to have the same antigenicity with the KN-2 strain (KN-2 like) based on the reactivity with 13 types of strain-specific or cross-reactive monoclonal antibodies to Karp, Gilliam, and Kato strains. Four isolates from 4 unfed larvae and adult of Leptotrombidium pallidum were also classified as the KN-3 like strains. Using indirect immunofluorescence, sera from 20 patients with tsutsugamushi disease were tested for reactivity with KN-1, KN-2, KN-3, and GJ-1 strains, isolated from patients in Gifu Prefecture. Fifteen sera showed the highest titer against KN-2 strain in Immunogloburin M (IgM). Of the other 5, three were higher for KN-3 strain in IgM, and two were KN-1 or GH, respectively. These results suggested that KN-2 like strains were prevalent in the region where the number of patients has been ranked the highest in Aichi Prefecture. KN-1, KN-3, and GJ-1 like strains were also existed in this area. KN-3 like strain was likely to be distributed in another area, Aichi Prefecture.

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 73 (12), 1194-1198, 1999

    The Japanese Association for Infectious Diseases

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