Cellular Substrates for Epileptiform Activity induced by Repeated Tetanic Stimulation in Hippocampal Slices

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Using intact and transected hippocampal slices, we investigated the relationship between CA3 am CAI subfields in the generation of stimulus train-induced bursting. In intact slices, spontaneous burst, , in CA3 always preceded those in CA1, whereas after-discharge bursts in CA3 followed those in CA1 when it was possible to distinguish differences in the burst onset. After transection between CA3 anc CAI, neither spontaneous nor triggered bursts could be induced or maintained in isolated CA1, where only small after-discharge bursts with higher bursting frequency were observed. Some of the mecha. nisms underlying the generation of these stimulus train-induced bursts are discussed.

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