PROGNOSTIC IMPORTANCE OF PROSTATE SPECIFIC ANTIGEN IN PATIENTS WITH HORMONALLY TREATED STAGE D2 PROSTATE CARCINOMA

DOI PubMed 7 Citations 21 References Open Access

Bibliographic Information

Other Title
  • 内分泌治療を施行した Stage D2前立腺癌におけるPSA値と予後の検討

Search this article

Description

(Background) The objective of this study is to evaluate the relationship between PSA value and prognosis of the patients with stage D2 prostate carcinoma.<br>(Methods) Serum prostate specific antigen was analyzed in 61 patients with stage D2 prostate carcinoma submitted to hormone therapy.<br>(Results) The median values of PSA parameters were 77.6ng/ml for the initial PSA, 91.8% for the maximal decrease, 2.7ng/ml for the nadir, 1.1 months for the half-life time, 3.0 months for the time to nadia, 3.2 months for the doubling time after progression and 0.39 for the ratio of antemortem versus initial PSA. The median biochemical progression-free time was 15.0 months and the median actuarial survival after progression was 24.9 months. The progression-free time was significantly correlated with the normalization of PSA (p<0.001) and the initial PSA of less than 100ng/ml (p<0.05), and the survival time after progression was significantly correlated with the doubling time (p<0.05). The normalization of PSA was affected by initial value, maximal decrease rate and and half-life time of PSA respectively, but not by the histological grade of the primary tumors. The doubling time was not correlated with these factors nor with the progression-free time.<br>(Conclusion) The results show that the initial value, nadir level and doubling time of PSA can be used as prognostic parameters for prostatic carcinoma. Both the low ratio of premortem versus initial PSA, which may reflect an increase of stem cell fraction, and the PSA doubling time after relapse, which seems similar to or shorter than that of untreated cases, will indicate an aggressive potential of hormone-refractory tumors.

Journal

Citations (7)*help

See more

References(21)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top