Favorable Outcome After Radical Resection and Subsequent Local Irradiation of Malignant Peripheral Nerve Sheath Tumor in the Cervical Spine
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- SASAMORI Toru
- Department of Neurosurgery, Hokkaido University Graduate School of Medicine
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- HIDA Kazutoshi
- Department of Neurosurgery, Hokkaido University Graduate School of Medicine
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- YANO Shunsuke
- Department of Neurosurgery, Sapporo Azabu Neurosurgical Hospital
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- AOYAMA Takeshi
- Department of Neurosurgery, Hokkaido University Graduate School of Medicine
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- ASANO Takeshi
- Department of Neurosurgery, Hokkaido University Graduate School of Medicine
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- KUBOTA Kanako
- Department of Pathology, Hokkaido University Hospital
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- ITO Manabu
- Department of Advanced Medicine for Spine and Spinal Cord Disorders, Hokkaido University Graduate School of Medicine
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- ABUMI Kuniyoshi
- Department of Spinal Reconstruction, Hokkaido University Graduate School of Medicine
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- IWASAKI Yoshinobu
- Department of Neurosurgery, Sapporo Azabu Neurosurgical Hospital
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- SAITO Hisatoshi
- Department of Neurosurgery, Sapporo Azabu Neurosurgical Hospital
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- HOUKIN Kiyohiro
- Department of Neurosurgery, Hokkaido University Graduate School of Medicine
書誌事項
- タイトル別名
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- —Case Report—
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A 25-year-old man presented with malignant transformation to malignant peripheral nerve sheath tumor (MPNST) in the cervical spine associated with neurofibromatosis type 1. He presented with a 3-week history of rapidly increasing weakness and numbness in all four extremities. Magnetic resonance (MR) imaging of the cervical spine demonstrated a dumbbell-shaped tumor, which compressed the spinal cord at the C2-3 level. The tumor was excised, mainly within the spinal canal to decompress the spinal cord. The histological diagnosis was benign neurofibroma. Three months after surgery, he rapidly developed progressive tetraparesis and MR imaging revealed marked regrowth of an extradural mass into the spinal canal. At reoperation, the regrown mass in the spinal canal was totally excised. The histological diagnosis revealed MPNST. He underwent radiation therapy, with a total dose of 32 Gy, for approximately 3 weeks after the second surgery, but MR imaging showed tumor regrowth within the spinal canal, and his condition deteriorated. The decision was made to remove the tumor radically, including the involved facet and extradural lesion. Posterior fusion using a pedicle screw was performed one month later. He manifested no additional neurological deficits. He has been free of relapse for 46 months. Radical resection remains the most effective treatment for MPNST, although complete removal with a clear tumor margin is often impossible in practice.<br>
収録刊行物
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- Neurologia medico-chirurgica
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Neurologia medico-chirurgica 52 (9), 670-674, 2012
一般社団法人 日本脳神経外科学会
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詳細情報 詳細情報について
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- CRID
- 1390001205056203904
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- NII論文ID
- 10030873164
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- NII書誌ID
- AN00358613
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- COI
- 1:STN:280:DC%2BC38bpslWlsQ%3D%3D
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- ISSN
- 13498029
- 04708105
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- PubMed
- 23006884
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- 本文言語コード
- en
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- データソース種別
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- JaLC
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- PubMed
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- 使用不可