SUCCESSFUL LONG-TERM MANAGEMENT OF HEPATIC AND LYMPH NODES METASTASES OF URETERAL CANCER BY MULTIMODAL TREATMENT INCLUDING RADIOFREQUENCY ABLATION

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  • Yasuda Yosuke
    Department of Urology, Graduate School, Tokyo Medical and Dental University
  • Tatokoro Manabu
    Department of Urology, Graduate School, Tokyo Medical and Dental University
  • Yokoyama Minato
    Department of Urology, Graduate School, Tokyo Medical and Dental University
  • Koga Fumitaka
    Department of Urology, Graduate School, Tokyo Medical and Dental University
  • Saito Kazutaka
    Department of Urology, Graduate School, Tokyo Medical and Dental University
  • Masuda Hitoshi
    Department of Urology, Graduate School, Tokyo Medical and Dental University
  • Fujii Yasuhisa
    Department of Urology, Graduate School, Tokyo Medical and Dental University
  • Kawakami Satoru
    Department of Urology, Graduate School, Tokyo Medical and Dental University
  • Kihara Kazunori
    Department of Urology, Graduate School, Tokyo Medical and Dental University

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Other Title
  • 集学的治療が奏効し，長期間良好なQOLを維持している尿管癌・肝/リンパ節転移の1例
  • 症例報告 集学的治療が奏効し,長期間良好なQOLを維持している尿管癌・肝/リンパ節転移の1例
  • ショウレイ ホウコク シュウガクテキ チリョウ ガ ソウコウ シ チョウキカン リョウコウ ナ QOL オ イジ シテ イル ニョウカンガン カン リンパセツ テンイ ノ 1レイ

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Abstract

A 56-year-old man presented with asymptomatic gross hematuria. Computed tomography (CT) scan revealed right hydronephrosis and a slightly enhanced invasive tumor in the right lower ureter, providing a diagnosis of ureteral cancer stage cT3N0M0. The patient underwent minimum incision endoscopic nephrouretectomy, and pathological examination of the resected specimen revealed urothelial carcinoma and squamous cell carcinoma with metastases to right obturator lymph nodes (pT3pN2).<br> Ten months later, CT scan of the abdomen revealed two hepatic metastases. After three courses of combination chemotherapy consisting of gemcitabine and cisplatin (GC), one tumor completely disappeared and another achieved a partial response. The patient underwent radiofrequency ablation (RFA) for the residual followed by GC chemotherapy. However, eighteen months later, CT scan of the abdomen revealed two metastatic foci in other hepatic lesion. The patient underwent RFA again followed by GC chemotherapy and then all hepatic metastases have not revealed enlargement. More than three years after surgery, the patient has achieved a high quality of life.<br>

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