Improvement of gastric motility by hemodialysis in patients with chronic renal failure

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  • Adachi Hiroshi
    Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences
  • Kamiya Takeshi
    Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences
  • Hirako Makoto
    Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences
  • Misu Naoko
    Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences
  • Kobayashi Yuka
    Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences
  • Shikano Michiko
    Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences
  • Matsuhisa Eriko
    Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences
  • Kataoka Hiromi
    Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences
  • Sasaki Makoto
    Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences
  • Ohara Hirotaka
    Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences
  • Nakao Haruhisa
    Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences
  • Orito Etsuro
    Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences
  • Joh Takashi
    Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences

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Background: Gastrointestinal (GI) symptoms are common in patients with chronic renal failure (CRF). We have previously demonstrated that patients with predialysis end-stage renal disease showed a high prevalence of GI symptoms and gastric hypomotility, and that gastric hypomotility appears to be an important factor in generating GI symptoms. However, it is not clear whether impaired gastric motor function would improve after hemodialytic treatment. Aims: To examine the relationship between gastric motor function and GI symptoms in CRF patients on hemodialysis. Methods: The study was performed in 19 patients with CRF treated with hemodialysis for more than six months and in 12 matched healthy controls. GI symptom severity was quantified in all patients. Gastric motility was evaluated with cutaneously recorded electrogastrography (EGG) and gastric emptying of semi-solid meals using the 13C-acetic acid breath test. Results: Six patients had no symptoms, and 11 had slight GI symptoms with a total symptom score of less than 5. Compared with controls, CRF patients revealed no differences in gastric motility parameters, with the exception of a lower percentage of normogastria in EGG at fasting state. Eleven patients had normal gastric motor function (Group A), and eight showed abnormalities of either gastric myoelectrical activity or gastric emptying (Group B). There was no difference in symptom score between Group A and Group B. Conclusions: More than half of the patients with CRF on hemodialysis demonstrated normal gastric motility, and no or slight GI symptoms. Hemodialytic treatment may improve impaired gastric motility and reduce GI symptoms in patients with CRF.<br>

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