Inflammasomes in viral infection

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  • ICHINOHE Takesh
    Department of Immunobiology, Yale University School of Medicine JSPS Postdoctoral Fellow for Research Abroad
  • IWASAKI Akiko
    Department of Immunobiology, Yale University School of Medicine

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Other Title
  • ウイルス感染におけるインフラマゾーム
  • ウイルス カンセン ニ オケル インフラマゾーム

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Description

The NOD-like receptors (NLRs) are a family of intracellular sensors of microbial motifs and damage-associated signals that have emerged as being a crucial component of the innate immune responses and inflammation. The inflammasome is a multiprotein complex, which include NLRs, their adaptor proteins and pro-caspase-1, that stimulates caspase-1 activation to promote the processing and secretion of proinflammatory cytokines interleukin 1β(IL-1β), IL-18 and Il-33, as well as “pyroptosis”, a form cell death induced by bacterial pathogens. Among the various inflammasomes, the NLRP3 inflammasome is triggered by diverse set of molecules and signals. Recent reports indicate that infection by certain viruses also results in inflammasome activation. Here, we review our current understanding of the mechanism by which various stimuli activate inflammasomes. Further, we discuss the role of inflammasomes in the induction of adaptive immunity against influenza virus infection.

Journal

  • Uirusu

    Uirusu 59 (1), 13-22, 2009

    The Japanese Society for Virology

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