Drug-induced hypersensitivity syndrome and HHV-6 reactivation

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  • TOHYAMA Mikiko
    Department of Dermatology, Ehime University Graduate School of Medicine
  • HASHIMOTO Koji
    Department of Dermatology, Ehime University Graduate School of Medicine

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  • 薬剤性過敏症症候群とＨＨＶ－６の再活性化について
  • ヤクザイセイ カビンショウ ショウコウグン ト HHV 6 ノ サイカッセイカ ニ ツイテ

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Abstract

Drug-induced hypersensitivity syndrome (DIHS) is an adverse reaction with clinical signs of fever, rash, and internal organ involvement. The culprit drugs of DIHS are limited to several drugs such as carbamazepine, phenytoin, phenobarbital, zonisamide, allopurinol, salazosulfapyridine, diaphenylsulphone, and mexiletine. The association of HHV-6 reactivation with DIHS has been known. Flaring of symptoms such as fever and hepatitis is closely related to HHV-6 reactivation. A combination of immunologic reaction to a drug and HHV-6 reactivation results in the severe course of DIHS.

Journal

  • Uirusu

    Uirusu 59 (1), 23-30, 2009

    The Japanese Society for Virology

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