Molecular evolution of physiologically functioning anti-retroviral APOBEC3 deaminases.

DOI Web Site PubMed 108 References

Bibliographic Information

Other Title
  • 生理的に機能するレトロウイルス複製制限因子APOBEC3の分子進化
  • セイリテキ ニ キノウ スル レトロウイルス フクセイ セイゲン インシ APOBEC3 ノ ブンシ シンカ

Search this article

Abstract

Recent in vivo findings clearly indicate that mammalian cytidine deaminase APOBEC3 can function as a physiological restriction factor to retrotransposons and infectious retroviruses. However, some retroviruses, including primate lentiviruses, have evolved to counter their natural host's APOBEC3. To survive this arms race, primates seem to have acquired multiple copies of APOBEC3 genes. Surprisingly, however, during the process of the diversification of rodent species, as well as the human race, some ancestral individuals acquired genetic variants that reduced the protein levels of APOBEC3 expression, and these variants currently show unexpectedly wide geographic distributions. These data suggest that in the absence of a heavy burden of infectious retroviruses, high-level expression of APOBEC3 cytidine deaminase might be costly to the integrity of the host genome.

Journal

  • Uirusu

    Uirusu 62 (1), 27-38, 2012

    The Japanese Society for Virology

References(108)*help

See more

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top