Bioinformatics studies on drug resistance against anti-HIV-1 drugs
-
- ODE Hirotaka
- Laboratory of Infectious Diseases, Clinical Research Center, National Hospital Organization Nagoya Medical Center
Bibliographic Information
- Other Title
-
- バイオインフォマティクスに基づくHIV-1の薬剤耐性研究
- バイオインフォマティクス ニ モトズク HIV 1 ノ ヤクザイ タイセイ ケンキュウ
Search this article
Abstract
More than 20 drugs have been available for anti-HIV-1 treatment in Japan. Combination therapy with these drugs dramatically decreases in morbidity and mortality of AIDS. However, due to high mutation rate of HIV-1, treatment with ineffective drugs toward patients infected with HIV-1 causes accumulation of mutations in the virus, and emergence of drug resistant viruses. Thus, to achieve appropriate application of the drugs toward the respective patients living with HIV-1, methods for predicting the level of drug-resistance using viral sequence information has been developed on the basis of bioinformatics. Furthermore, ultra-deep sequencing by next-generation sequencer whose data analysis is also based on bioinformatics, or in silico structural modeling have been achieved to understand drug resistant mechanisms. In this review, I overview the bioinformatics studies about drug resistance against anti-HIV-1 drugs.
Journal
-
- Uirusu
-
Uirusu 61 (1), 35-48, 2011
The Japanese Society for Virology
- Tweet
Keywords
Details 詳細情報について
-
- CRID
- 1390001205078222208
-
- NII Article ID
- 130004470964
- 10029357118
-
- NII Book ID
- AN00018808
-
- COI
- 1:CAS:528:DC%2BC3MXht1ahsLzI
-
- ISSN
- 18843433
- 00426857
-
- NDL BIB ID
- 11170318
-
- PubMed
- 21972554
-
- Text Lang
- ja
-
- Data Source
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- Abstract License Flag
- Disallowed