風疹ウイルス感染症における血清学的研究―とくにクラス別免疫グロブリン抗体の測定法とその消長について―

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タイトル別名
  • STUDIES ON SPECIFIC IMMUNOGLOBULIN RESPONSES IN SERUM AFTER SPONTANEOUS INFECTION WITH RUBELLA VIRUS
  • フウシン ウイルス カンセンショウ ニ オケル ケッセイガクテキ ケンキュウ
  • II. PERSISTENCE OF RUBELLA IgM AND IgA HEMAGGLUTINATION-INHIBITION ANTIBODIES AFTER SPONTANEOUS INFECTION
  • II. 風疹ウイルス感染症におけるIgMおよびIgA風疹赤血球凝集抑制抗体の消長

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抄録

It is of great importance to determine by immunological methods whether pregnant women had a recent or a remote rubella infection. In the previous report the presence of rubella-specific IgM antibody was suggested to indicate a recent rubella infection. The persistence of the specific IgM antibody, however, was not sufficiently clarified.<br>In the present study 374 serum specimens were obtained from 137 cases over a period of 540 days after the onset of rubella rash. They were tested for rubella-specific IgM plus IgA HI antibodies, IgM antibodies, and IgA antibodies by using the staphylococcal absorption method, fractionation by sucrose density gradient centrifugation, and a combination of both methods mentioned above, respectively. Specific IgM and IgA antibodies appeared in the acute stage of rubella. IgM antibody persisted for 10 months and IgA antibody up to one year and a half after infection. In some cases both antibodies disappeared 3 months after infection.<br>The interpretation of the residual rubella HI antibody titers in the serum after absorption with S. aureus was as follows: Titers of 1: 32 and higher indicated a recent infection within 3 months, but any titer of less than 1:8 did not. Titers of 1:8 and 1:16 did not explain the time of infection. Specific JgM and IgA antibodies appearing after natural rubella infection persisted longer than those reported previously. So that for the serological diagnosis the efficacy of the staphylococcal absorption method was limited to the detection of a recent rubella infection.

収録刊行物

  • ウイルス

    ウイルス 28 (2), 95-102, 1978

    日本ウイルス学会

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