Analytic and integrative perspectives for HIV vaccine design

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  • HIVワクチン開発への分析的・統合的視点
  • HIV ワクチン カイハツ エ ノ ブンセキテキ ・ トウゴウテキ シテン

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Abstract

Prophylactic AIDS vaccines are required to optimally load adaptive immune responses against a virus optimally designed to impair those responses and induce persistent infection. This inevitably may necessitate atypical induction patterns that are distinct from well-balanced responses deriving from the inherent immunological framework. This review discusses how the diverse features of pathologic context-dependent T-cell (CTL/Th) and B-cell (neutralizing antibody) responses may be incorporated into vaccine-induced immunity to achieve HIV control in vivo.

Journal

  • Uirusu

    Uirusu 63 (2), 219-232, 2013

    The Japanese Society for Virology

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