Epidemiological and basic research activity targeting polyomaviruses

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  • SAWA Hirofumi
    Division of Molecular Pathobiology, Hokkaido University Research Center for Zoonosis Control
  • KOBAYASHI Shintaro
    Division of Molecular Pathobiology, Hokkaido University Research Center for Zoonosis Control
  • SUZUKI Tadaki
    Department of Pathology, National Institute of Infectious Diseases
  • ORBA Yasuko
    Department of Pathology, National Institute of Infectious Diseases

Bibliographic Information

Other Title
  • ポリオーマウイルスの疫学研究と基礎研究
  • ポリオーマウイルス ノ エキガク ケンキュウ ト キソ ケンキュウ

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Abstract

Recently, the family Polyomaviridae was classified as 3 genera, such as Orthopolyomavirus, Wukipolyomavirus which contain mammalian polyomaviruses and Avipolyomavirus which only contain avian polyomaviruses. We have recently isolated novel polyomaviruses, including Mastomys Polyoamvirus (MasPyV) and Vervet monkey Polyoamvirus-1 (VmPyV-1) by epidemiological activities and examined functions of their encoding proteins. In addition, we have been investigating the mechanisms of replication of human polyomavirus, JC polyomavirus (JCPyV). We recently obtained the results of function of JCVPyV-encoding proteins, including early protein (Large T antigen) and late proteins (VP1 and Agno). In this review, we summarized the data of our basic research activities.

Journal

  • Uirusu

    Uirusu 64 (1), 25-34, 2014

    The Japanese Society for Virology

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