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A reverse genetics system for flaviviruses
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- SUZUKI Ryosuke
- Department of Virology II, National Institute of Infectious Diseases
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- KONISHI Eiji
- BIKEN Endowed Department of Dengue Vaccine Development, Faculty of Tropical Medicine, Mahidol University
Bibliographic Information
- Other Title
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- フラビウイルスのリバースジェネティクス
- フラビウイルス ノ リバースジェネティクス
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Description
Flaviviruses such as Japanese encephalitis virus, West Nile virus, yellow fever virus, dengue virus, and tick-borne encephalitis virus belong to a family Flaviviridae. These viruses are transmitted to vertebrates by infected mosquitoes or ticks, producing diseases, which have a serious impact on global public health. Reverse genetics is a powerful tool for studying the viruses. Although infectious full-length clones have been obtained for multiple flaviviruses, their early-stage development had the difficulty because of the instability problem of the viral cDNA in E. coli. Several strategies have been developed to circumvent the problem of infectious clone instability. The current knowledge accumulated on reverse genetics system of flaviviruses and its application are summarized in this review.
Journal
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- Uirusu
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Uirusu 63 (1), 13-22, 2013
The Japanese Society for Virology
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Keywords
Details 詳細情報について
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- CRID
- 1390001205078953984
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- NII Article ID
- 10031187699
- 40019768112
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- NII Book ID
- AN00018808
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- COI
- 1:CAS:528:DC%2BC2cXisFKksrg%3D
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- ISSN
- 18843433
- 00426857
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- NDL BIB ID
- 024804938
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- PubMed
- 24769573
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- Text Lang
- ja
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- Article Type
- journal article
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- Data Source
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- JaLC
- NDL Search
- Crossref
- PubMed
- CiNii Articles
- OpenAIRE
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- Abstract License Flag
- Disallowed