Multifunctional HIV accessory proteins are hub proteins antagonizing host antiviral factors

DOI Web Site PubMed 100 References
  • KITAMURA Shingo
    National Hospital Organization Nagoya Medical Center, Clinical Research Center
  • IWATANI Yasumasa
    National Hospital Organization Nagoya Medical Center, Clinical Research Center

Bibliographic Information

Other Title
  • HIVアクセサリータンパク質の機能
  • HIV アクセサリータンパクシツ ノ キノウ

Search this article

Abstract

HIV has several accessory proteins (Vif, Vpu, Vpr, Vpx, and Nef) along with structural /enzymatic (Gag, Pol, and Env) and gene-expression regulatory proteins (Tat and Rev) essential for viral replication. The accessory proteins are neither required in some kinds of cells and nor all conserved between HIV-1 and HIV-2. For these reasons, their functional roles and mechanisms had been unclear. However, since a finding of Vif’s neutralizing function against host restriction factor APOBEC3G, it has been elucidated that the accessory proteins play critical roles to antagonize host intrinsic antiviral activity. So far, in addition to Vif-APOBEC3, Vpu-BST-2/Tetherin and Vpx-SAMHD1 have been identified as such examples. Here, we summarize the biological functions and features on HIV accessory proteins in terms of antagonizing factors against the host antiviral factors.

Journal

  • Uirusu

    Uirusu 63 (2), 187-198, 2013

    The Japanese Society for Virology

References(100)*help

See more

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top