Cellular tropism and adaptation of the measles virus.

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  • OHNO Shinji
    Department of Virology, Faculty of Medicine, Kyushu University
  • YANAGI Yusuke
    Department of Virology, Faculty of Medicine, Kyushu University

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Other Title
  • １．麻疹ウイルスのトロピズムと培養細胞への馴化
  • 麻疹ウイルスのトロピズムと培養細胞への馴化
  • マシン ウイルス ノ トロピズム ト バイヨウ サイボウ エ ノ ジュンカ

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Abstract

Measles virus (MV) is a member of the genus Morbillivirus in the family Paramyxoviridae. Clinical isolates of MV use signaling lymphocyte activating molecule (SLAM) as a cellular receptor. SLAM is mainly expressed on immune cells such as immature thymocytes, activated lymphocytes and mature dendritic cells. This distribution of SLAM can account for the lymphotropism of MV. On the other hand, laboratory strains of MV use CD46 as an alternative receptor, through amino acid change(s) in the receptor binding hemagglutinin protein. Recently, several reports imply the existence of the cellular receptor(s) other than SLAM and CD46. In this review, we discuss the receptor usage of MV and its adaptation to cultured cells.

Journal

  • Uirusu

    Uirusu 56 (1), 27-34, 2006

    The Japanese Society for Virology

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