HTLV Research 30th Year

DOI Web Site PubMed 52 References

Bibliographic Information

Other Title
  • HTLV研究30年
  • HTLV ケンキュウ 30ネン

Search this article

Abstract

This year is 30th year since HTLV was first reported as a causative agent for ATL. From a series of extensive studies especially by Japanese researches, a variety of information is now available, such as characteristics of the virus, regulation of viral and/or cell gene expression by HTLV-encoded protein Tax and Rex, the pathway of activation machinery on cell growth, the mechanism of cell-to-cell transmission, and prevalence of HTLV carries. However, it remains unsolved how HIV-1 invades and enters into human, how HIV-1 replicates in vivo, how the tumor cells are selected during course of infection, and which cellular molecules contribute disease onset and progression. It was thought the mechanism of HTLV-related diseases, ATL and HAM, would be quickly revealed earlier time after HTLV discovery since the HTLV-related diseases show unique characteristics. Nevertheless, we do not have yet satisfied knowledge of the pathogenesis mechanism as well as the treatment. I describe the history and perspective.

Journal

  • Uirusu

    Uirusu 61 (2), 175-182, 2011

    The Japanese Society for Virology

References(52)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top