HTLV Research 30th Year
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- KOYANAGI Yoshio
- Institute for Virus Research, Kyoto University
Bibliographic Information
- Other Title
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- HTLV研究30年
- HTLV ケンキュウ 30ネン
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Description
This year is 30th year since HTLV was first reported as a causative agent for ATL. From a series of extensive studies especially by Japanese researches, a variety of information is now available, such as characteristics of the virus, regulation of viral and/or cell gene expression by HTLV-encoded protein Tax and Rex, the pathway of activation machinery on cell growth, the mechanism of cell-to-cell transmission, and prevalence of HTLV carries. However, it remains unsolved how HIV-1 invades and enters into human, how HIV-1 replicates in vivo, how the tumor cells are selected during course of infection, and which cellular molecules contribute disease onset and progression. It was thought the mechanism of HTLV-related diseases, ATL and HAM, would be quickly revealed earlier time after HTLV discovery since the HTLV-related diseases show unique characteristics. Nevertheless, we do not have yet satisfied knowledge of the pathogenesis mechanism as well as the treatment. I describe the history and perspective.
Journal
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- Uirusu
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Uirusu 61 (2), 175-182, 2011
The Japanese Society for Virology
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Keywords
Details 詳細情報について
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- CRID
- 1390001205079239296
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- NII Article ID
- 130004470975
- 10030577862
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- NII Book ID
- AN00018808
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- COI
- 1:CAS:528:DC%2BC38XltlGgsr0%3D
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- ISSN
- 18843433
- 00426857
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- NDL BIB ID
- 023466098
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- PubMed
- 22916564
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed