Chronic Active Epstein-Barr Virus Infection

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  • KIMURA Hiroshi
    Department of Virology, Nagoya University Graduate School of Medicine

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Other Title
  • 慢性活動性EBV感染症
  • マンセイ カツドウセイ EBV カンセンショウ

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Abstract

The ubiquitous Epstein-Barr virus (EBV), which establishes latency after primary infection, does not cause any symptomatic diseases as long as cellular immunity is intact. In apparently immunocompetent individuals, a chronic infection can develop, and this has been called as chronic active EBV infection (CAEBV). CAEBV is characterized by chronic or recurrent infectious mononucleosis-like symptoms, such as fever, extensive lymphadenopathy, and, hepatosplenomegaly. This disease is rare but severe with high morbidity and mortality. Recently, its pathophysiology is not an infection but a clonal expansion of EBV-infected T or natural killer NK cells. In this review, I discuss our current understanding of the pathogenesis of CAEBV and summarize its clinical features, therapies, and prognosis.

Journal

  • Uirusu

    Uirusu 61 (2), 163-174, 2011

    The Japanese Society for Virology

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