Acrylamide Does Not Cause Apparent Changes in Genetic Expression of Creatine Kinase in Rat Cerebellum

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  • WISPRIYONO Bambang
    Department of Environmental Toxicology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health
  • MATSUOKA Masato
    Department of Environmental Toxicology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health
  • IGISU Hideki
    Department of Environmental Toxicology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health

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Other Title
  • アクリルアミドはラット小脳におけるクレアチンキナーゼ発現に明らかな影響を及ぼさない

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Abstract

Acrylamide inhibits creatine kinase (CK) activities in the brain of rats or mice. However, its effects on genetic expression of CK have not yet been studied. CK mRNA and protein level were examined by RT-PCR and Western blotting, respectively. Neither cytosolic CK (B subunit) and mitochondrial CK (ubiquitous form) mRNA nor B subunit protein was clearly changed in the cerebellum from rats intoxicated with acrylamide (50 mg/kg/day ip for 8 days) and showing clinical neurotoxic signs.

Journal

  • Journal of UOEH

    Journal of UOEH 26 (1), 51-57, 2004

    The University of Occupational and Environmental Health, Japan

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