Vasculogenesis and Angiogenesis

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  • DOI Yoshiaki
    Department of Anatomy, School of Medicine, University of Occupational and Environmental Health
  • KUDO Hideaki
    Department of Anatomy, School of Medicine, University of Occupational and Environmental Health
  • NISHINO Tomoko
    Department of Anatomy, School of Medicine, University of Occupational and Environmental Health
  • FUJIMOTO Sunao
    Health and Nutritional Sciences, Nakamura Gakuen University Graduate School

Bibliographic Information

Other Title
  • 血管発生と血管新生 ―新生血管形成に関する研究の沿革―
  • ケッカン ハッセイ ト ケッカン シンセイ シンセイ ケッカン ケイセイ ニ カンスル ケンキュウ ノ エンカク

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Description

Vasculogenesis is defined as a neovascularization manner by which endothelial progenitor cells are successively incorporated into the growing capillaries, whereas angiogenesis is another neovascularization manner which includes mitotic proliferations of endothelial cells of the preexisting capillaries and their migration to the vascular tips forming so called "vascular sprouts" or "endothelial buds". Although angiogenesis had been considered to be more prevalent during organogenesis as well as during a wound healing process of adult mammals, recent findings that endothelial progenitor cells were isolated from human peripheral blood and incorporated into sites of active neovascularization have led many researchers to recognize the significance of vasculogenesis in a phenomenon of neovascularization. This paper mainly deals with the history of morphological approaches to clarify the crucial roles of vasculogenesis during organogenesis and a wound healing process.

Journal

  • Journal of UOEH

    Journal of UOEH 25 (4), 409-417, 2003

    University of Occupational and Environmental Health, Japan

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