Hyperferritinemia and Diseases

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  • OTA Toshiyuki
    Department of Central Clinical Laboratory, University Hospital, University of Occupational and Environmental Health

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Other Title
  • 高フェリチン血症と疾患
  • コウフェリチン ケツショウ ト シッカン

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Description

Ferritin is the principal iron storage protein participating in iron metabolism. As serum ferritin levels often reflect the amount of storage iron in the body, physicians have measured serum ferritin in order to evaluate iron deficiency or overload. Although a rise in serum ferritin concentration occurs in iron overload, hyperferritinemia without it has been reported in some inflammatry diseases and malignancies. Some cytokines have been reported to be responsible for the elevation of ferritin production. Studies on serum isoferritin in adult Still's disease and other diseases, especially measurements of the proportion of glycosylated ferritin, have been widely accepted. Pathophysiological properties of the increased serum ferritin are not clear. However, we should be aware that the hyperferritinemia is not a result, but is profoundly participating in the disease process.

Journal

  • Journal of UOEH

    Journal of UOEH 22 (2), 189-200, 2000

    University of Occupational and Environmental Health, Japan

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