Secondary Adrenocortical Insufficiency Complicated by Marked Hypercalcemia and Eosinophilia: A Case Report

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  • YAMAMOTO Sunao
    The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan
  • OKADA Yosuke
    The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan
  • ARAO Tadashi
    The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan
  • TANAKA Yoshiya
    The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan

Bibliographic Information

Other Title
  • 著明な高カルシウム血症と末梢血好酸球増多を呈した続発性副腎皮質機能低下症の1例
  • 症例報告 著明な高カルシウム血症と末梢血好酸球増多を呈した続発性副腎皮質機能低下症の1例
  • ショウレイ ホウコク チョメイ ナ コウカルシウム ケツショウ ト マッショウケツ コウサンキュウ ゾウ タ オ テイシタ ゾクハツセイ フクジン ヒシツ キノウ テイカショウ ノ 1レイ

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Abstract

A 56 year old female was admitted to a local hospital after developing symptoms, including generalized fatigue, nausea and vomiting, from trauma. She was relocated to our hospital because she developed other symptoms, including disturbance of consciousness from hypercalcemia and a rash over her entire body. Her clinical symptoms (disturbance of consciousness, loss of appetite, nausea, vomiting, decrease in blood pressure, fever) and examination findings (low blood cortisol levels (1.2 μg/dl ), hypercalcemia (11.0 mg/dl ), peripheral blood eosinophilia (1,600 /μl )) lead to a diagnosis of adrenal insufficiency. In addition, a skin biopsy indicated eosinophilic infiltration, although her condition improved in the end with an oral dose of 30 mg/day of prednisolone. Hypercalcemia and peripheral blood eosinophilia are commonly known examination findings for adrenocortical insufficiency, but it is rare for either of these to be present as clinical symptoms.

Journal

  • Journal of UOEH

    Journal of UOEH 37 (1), 55-60, 2015-03-01

    The University of Occupational and Environmental Health, Japan

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