Mechanical Control of Cellular Function via Elastic Extracellular Matrix Environment(Papers presented at the Seminar, "Biological mechanism of stress perception")

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  • HARADA Ichiro
    Graduated School of Bioscience and Biotechnology, Tokyo Institute of Technology

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  • 生体内細胞の力学環境場に対する応答性(セミナー「生物のストレス受容のメカニズム-分子レベルから細胞レベルまで-」)
  • 生体内細胞の力学環境場に対する応答性
  • セイタイナイ サイボウ ノ リキガク カンキョウバ ニ タイスル オウトウセイ

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Abstract

Mechanical force plays an important role in the interactions of cells with the extracellular matrix (ECM) in many tissues. The cell-ECM mechanical interactions affect cellular behaviors such as adhesion, proliferation, differentiation, and survival by activating intracellular signal transduction pathways. However, the molecular mechanisms on mechanical interactions between cells and ECMs remain incomplete owing to the difficulty to find out a molecule or event cues the signal of force transduction. To answer this question, it is necessary to measure the force exerted to the all adherent point and amount of activated molecules recruited to all that point at same time. For this purpose, we developed a new 3D micro- hydrogel pillars substrate based on a two- photon initiate polymerization technique. We found that cell can migrate on top of the substrate and cellular forces can be measured by deflection of each pillar during cellular migration.

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