Application of Isothermal Microcalorimetry for Stability Evaluation of Solid Dosage Form

DOI

Bibliographic Information

Other Title
  • 固体医薬品の安定性評価と微少熱量計の応用

Description

This review demonstrated the possibility of application of isothermal microcalorimetry (IMC) for stability evaluation of solid dosage form. Various kinetic equations derived from the different reaction model in the solid state were applied for the obtained data using isothermal microcalorimeter. Suitable decomposition rate constant was successfully derived from the most appropriate kinetic equation evaluated by curve fitting method. Experimental decomposition rate constant of solid dosage form was determined by the time-consuming conventional method, which took more than 6 months. The predicted values were in good agreement with the experimental values. By using this method, the stability of solid dosage form can be predicted by a simple operation in a short time. Application of IMC would be useful for the screening test for the drug stability.

Journal

  • Netsu Sokutei

    Netsu Sokutei 31 (2), 80-86, 2004

    The Japan Society of Calorimetry and Thermal Analysis

Details 詳細情報について

  • CRID
    1390001205089874432
  • NII Article ID
    130003658794
  • DOI
    10.11311/jscta1974.31.80
  • ISSN
    18841899
    03862615
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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